Jacob Teresa V, Doshi Gaurav M
Department of Pharmacology, SVKM's Dr. Bhanuben Nanavati College of Pharmacy, V.M. Road, Vile Parle (W), Mumbai, 400056, India.
Endocr Metab Immune Disord Drug Targets. 2024;24(3):277-290. doi: 10.2174/1871530323666230824161901.
is the most thoroughly researched etiological component for stomach inflammation and malignancies. Even though there are conventional recommendations and treatment regimens for eradicating , failure rates continue to climb. Antibiotic resistance contributes significantly to misdiagnoses, false positive results, and clinical failures, all of which raise the chance of infection recurrence. This review aims to explore the molecular mechanisms underlying drug resistance in and discuss novel approaches for detecting genotypic resistance. Modulation of drug uptake/ efflux, biofilm, and coccoid development. Newer genome sequencing approaches capable of detecting genotypic resistance are presented. Prolonged infection in the stomach causes major problems such as gastric cancer. The review discusses how causes stomach cancer, recent biomarkers such as miRNAs, molecular pathways in the development of gastric cancer, and diagnostic methods and clinical trials for the disease. Efforts have been made to summarize the recent advancements made toward early diagnosis and novel therapeutic approaches for -induced gastric cancer.
是对胃炎症和恶性肿瘤研究最为深入的病因学因素。尽管有根除它的传统建议和治疗方案,但失败率仍在不断攀升。抗生素耐药性是导致误诊、假阳性结果和临床治疗失败的重要因素,所有这些都增加了感染复发的几率。本综述旨在探讨其耐药性的分子机制,并讨论检测基因型耐药性的新方法。药物摄取/外排、生物膜和球状体发育的调节。介绍了能够检测其基因型耐药性的更新的基因组测序方法。胃内的长期感染会引发诸如胃癌等重大问题。该综述讨论了它如何导致胃癌、近期的生物标志物如微小RNA、胃癌发展中的分子途径以及该疾病的诊断方法和临床试验。已努力总结在-诱导的胃癌早期诊断和新治疗方法方面取得的最新进展。 (注:原文中“-induced gastric cancer”处“-”指代不明,翻译时保留原样)