Department of Physics, Yonsei University, Seoul 03722, Republic of Korea.
Department of Biomedical Engineering, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea.
Biosensors (Basel). 2023 Aug 15;13(8):817. doi: 10.3390/bios13080817.
We present a fiber-optic sensor based on the principles of a Fabry-Perot interferometer (FPI), which promptly, sensitively, and precisely detects blood clot formation. This sensor has two types of sensor tips; the first was crafted by splicing a tapered fiber into a single-mode fiber (SMF), where fine-tuning was achieved by adjusting the tapered diameter and length. The second type is an ultra-compact blood FPI situated on the core of a single-mode fiber. The sensor performance was evaluated via clot-formation-indicating spectrum shifts induced by the varied quantities of a thrombin reagent introduced into the blood. The most remarkable spectral sensitivity of the micro-tip fiber type was approximately 7 nm/μL, with a power sensitivity of 4.1 dB/μL, obtained with a taper fiber diameter and length of 55 and 300 μm, respectively. For the SMF type, spectral sensitivity was observed to be 8.7 nm/μL, with an optical power sensitivity of 0.4 dB/μL. This pioneering fiber-optic thrombosis sensor has the potential for in situ applications, healthcare, medical monitoring, harsh environments, and chemical and biological sensing. The study underscores the scope of optical technology in thrombus detection, establishing a platform for future medical research and application.
我们提出了一种基于法布里-珀罗干涉仪（FPI）原理的光纤传感器，该传感器能够快速、灵敏、精确地检测血栓形成。该传感器有两种类型的传感器探头；第一种是通过将锥形光纤拼接成单模光纤（SMF）制成的，通过调整锥形直径和长度来实现微调。第二种是位于单模光纤芯上的超紧凑血液 FPI。通过向血液中引入不同量的凝血酶试剂来测量传感器性能，从而评估指示血栓形成的光谱位移。微尖端光纤类型的最显著光谱灵敏度约为 7nm/μL，功率灵敏度为 4.1dB/μL，分别使用直径和长度为 55μm 和 300μm 的锥形光纤获得。对于 SMF 型，观察到的光谱灵敏度为 8.7nm/μL，光功率灵敏度为 0.4dB/μL。这种开创性的光纤血栓传感器具有在原位应用、医疗保健、医疗监测、恶劣环境以及化学和生物传感方面的应用潜力。该研究强调了光学技术在血栓检测中的应用范围，为未来的医学研究和应用建立了一个平台。
