College of Information Science and Engineering, Northeastern University, Shenyang, China.
Hebei Key Laboratory of Micro-Nano Precision Optical Sensing and Measurement Technology, Qinhuangdao, China.
J Biophotonics. 2021 Jun;14(6):e202100068. doi: 10.1002/jbio.202100068. Epub 2021 Apr 30.
Optical fiber biosensors have attracted extensive research attention in fields such as public health research, environmental science, bioengineering, disease diagnosis and drug research. Accurate detection of biomolecules is essential to limit the extent of disease outbreaks and provide valuable guidance for regulatory agencies to take timely measures. Among many optical fiber sensors, optical fiber biosensors based on specialty fibers have the advantages of biocompatibility, small size, high measurement resolution, high stability and immunity to electromagnetic interference. In this paper, four types interferometer biosensors based on specialty fiber, namely Mach-Zehnder interferometer, Michelson interferometer, Fabry - Perot interferometer and Sagnac interferometer, are reviewed in terms of operating principles, sensing structure and application fields. The fiber types are further divided into micro-nano optical fiber, thin core fiber, polarization maintaining fiber, polymer fiber, microstructure optical fiber. Furthermore, this paper evaluates the advantages and disadvantages of these interferometer biosensors. Finally, main challenging problems and expectational development direction of specialty fiber interferometer biosensors are summarized. This text clearly shows the huge development potential of optical fiber biosensors in biomedical.
光纤生物传感器在公共卫生研究、环境科学、生物工程、疾病诊断和药物研究等领域引起了广泛的研究关注。准确检测生物分子对于限制疾病爆发的程度至关重要，并为监管机构提供了及时采取措施的宝贵指导。在众多光纤传感器中，基于特种光纤的光纤生物传感器具有生物相容性、体积小、测量分辨率高、稳定性好、抗电磁干扰等优点。本文从工作原理、传感结构和应用领域等方面综述了基于特种光纤的四种干涉仪生物传感器，即马赫-曾德尔干涉仪、迈克尔逊干涉仪、法布里-珀罗干涉仪和萨格纳克干涉仪。进一步将光纤类型分为微纳光纤、少模光纤、保偏光纤、聚合物光纤、微结构光纤。此外，本文还对这些干涉仪生物传感器的优缺点进行了评估。最后，总结了特种光纤干涉仪生物传感器的主要挑战性问题和预期发展方向。本文清楚地表明了光纤生物传感器在生物医学领域具有巨大的发展潜力。
