Karanian J W, D'Souza N B, Salem N
Life Sci. 1986 Oct 6;39(14):1245-55. doi: 10.1016/0024-3205(86)90185-2.
Rats were exposed to alcohol vapor for 6 days and the mean blood ethanol concentration (BEC) was obtained for each subject. Blood pressure and its reactivity to noradrenaline and a thromboxane-mimic U46619 were directly measured on day 6 via a catheter implanted in the tail artery of normal and ethanol-treated animals. The mean BEC for each subject correlated with mean arterial blood pressure (MAP); an increase in BEC was associated with a decrease in MAP (p less than 0.02). The mean MAP of subjects with BEC less than 168 mg% was 8% higher than normal (not significant), whereas, the mean MAP of subjects with BEC greater than 182 mg% decreased 27 +/- 4% (p less than 0.01). Conversely, the pressor response to U46619 was markedly enhanced (p less than 0.005) in rats with mean BEC greater than 182 mg% at all doses investigated (12.5-3200 ng per rat). Increases in the pressor response to noradrenaline in ethanol-treated rats were significant only when maximally stimulated by 400 and 800 ng doses (p less than 0.03). A 3-fold increase in sensitivity for U46619 was seen in subjects with high mean BEC, however, sensitivity for noradrenaline did not significantly change. Vasoreactivity was not effected in rats with mean BEC less than 168 mg%. These data demonstrate that a moderate mean BEC for 6 days induces a tendency towards a mild hypertension, whereas, high mean BEC induces marked hypotension which is associated with hyperreactivity. Long-term exposure to high blood ethanol concentrations may predispose the alcohol-dependent rats to hypertensive disease and vasospastic disorders, at least partially, as a result of enhanced sensitivity to prostaglandins such as thromboxane.
将大鼠暴露于酒精蒸汽中6天，测量每只大鼠的平均血液乙醇浓度（BEC）。在第6天，通过植入正常和乙醇处理动物尾动脉的导管直接测量血压及其对去甲肾上腺素和血栓素类似物U46619的反应性。每只大鼠的平均BEC与平均动脉血压（MAP）相关；BEC升高与MAP降低相关（p<0.02）。BEC低于168mg%的大鼠平均MAP比正常高8%（无统计学意义），而BEC高于182mg%的大鼠平均MAP降低27±4%（p<0.01）。相反，在所有研究剂量（每只大鼠12.5 - 3200ng）下，平均BEC大于182mg%的大鼠对U46619的升压反应显著增强（p<0.005）。乙醇处理的大鼠对去甲肾上腺素升压反应的增加仅在400和800ng剂量最大刺激时显著（p<0.03）。平均BEC高的大鼠对U46619的敏感性增加了3倍，然而，对去甲肾上腺素的敏感性没有显著变化。平均BEC低于168mg%的大鼠血管反应性未受影响。这些数据表明，6天的中度平均BEC会导致轻度高血压倾向，而高平均BEC会导致明显的低血压，并伴有反应性亢进。长期暴露于高血液乙醇浓度可能使酒精依赖大鼠易患高血压疾病和血管痉挛性疾病，至少部分原因是对血栓素等前列腺素的敏感性增强。
