Baena-Montes Jara M, Kraśny Marcin J, O'Halloran Martin, Dunne Eoghan, Quinlan Leo R
Physiology and Cellular Physiology Research Laboratory, School of Medicine, Human Biology Building, University of Galway, H91 TK33 Galway, Ireland.
Smart Sensors Lab, Lambe Institute for Translational Research, School of Medicine, University of Galway, H91 TK33 Galway, Ireland.
J Pers Med. 2023 Aug 8;13(8):1237. doi: 10.3390/jpm13081237.
Atrial fibrillation is the most common type of cardiac arrhythmias in humans, mostly caused by hyper excitation of specific areas in the atrium resulting in dyssynchronous atrial contractions, leading to severe consequences such as heart failure and stroke. Current therapeutics aim to target this condition through both pharmacological and non-pharmacological approaches. To test and validate any of these treatments, an appropriate preclinical model must be carefully chosen to refine and optimise the therapy features to correctly reverse this condition. A broad range of preclinical models have been developed over the years, with specific features and advantages to closely mimic the pathophysiology of atrial fibrillation. In this review, currently available models are described, from traditional animal models and in vitro cell cultures to state-of-the-art organoids and organs-on-a-chip. The advantages, applications and limitations of each model are discussed, providing the information to select the appropriate model for each research application.
心房颤动是人类最常见的心律失常类型，主要由心房特定区域的过度兴奋导致心房收缩不同步引起，进而导致心力衰竭和中风等严重后果。目前的治疗方法旨在通过药物和非药物途径来针对这种病症。为了测试和验证这些治疗方法中的任何一种，必须谨慎选择合适的临床前模型，以完善和优化治疗特性，从而正确逆转这种病症。多年来已经开发了广泛的临床前模型，它们具有特定的特征和优势，能够紧密模拟心房颤动的病理生理学。在这篇综述中，描述了目前可用的模型，从传统动物模型和体外细胞培养到最先进的类器官和芯片上器官。讨论了每种模型的优点、应用和局限性，为每种研究应用选择合适的模型提供信息。
