[用甲硫米特阻断H2受体对大鼠应激性溃疡的评估]
[Evaluation of H2 receptor blockade with metiamide in stress ulcers in rats].
作者信息
Lang G, Schwille P O, Thun R, Schellerer W
出版信息
Chir Forum Exp Klin Forsch. 1977 Apr:212-6.
PMID:376239
Abstract
Restrain stress in rats inhibits gastric secretion and microcirculation. Secretion is further inhibited by metiamide, but mucosal blood flow is restored to normal. During stress the ulcer incidence is high, lower with prophylactic administration of metiamide and least with the latter and preserved gastroduodenal acid transit. No therapeutic metiamide effect can be detected.
摘要
抑制大鼠的应激反应可抑制胃酸分泌和微循环。甲硫咪胺可进一步抑制胃酸分泌，但可使黏膜血流恢复正常。应激期间溃疡发生率很高，预防性给予甲硫咪胺可降低溃疡发生率，同时给予甲硫咪胺并保持胃十二指肠酸转运正常时溃疡发生率最低。未检测到甲硫咪胺的治疗效果。
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