组胺H1和H2受体介导的大鼠胃应激性溃疡病因中胃微循环效应
Histamine H1- and H2-receptor-mediated gastric microcirculatory effects in the aetiology of stress ulceration in the rat stomach.
作者信息
Cho C H, Ogle C W
出版信息
Experientia. 1978 Oct 15;34(10):1294-6. doi: 10.1007/BF01981427.
PMID:570118
Abstract
Stress produced severe mucosal ulcers, increased mucosal microcirculation and lowered mast cell counts in the glandular wall of rat stomachs. Mepyramine i.m. or metiamide i.p. effectively prevented both ulceration and microcirculatory changes but not stress-reduced mast cell counts.
摘要
应激可导致大鼠胃黏膜出现严重溃疡、黏膜微循环增加以及胃腺壁肥大细胞数量减少。腹腔注射甲氧苄二胺或肌内注射甲硫米特可有效预防溃疡形成和微循环变化，但不能阻止应激导致的肥大细胞数量减少。
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