Institute of Neuroscience, 1254 University of Oregon, Eugene, Oregon, USA.
Dev Growth Differ. 2023 Oct;65(8):453-458. doi: 10.1111/dgd.12888. Epub 2023 Sep 16.
Autism spectrum disorder (ASD) is one of the most common, heritable neuropsychiatric disorders in the world, affecting almost 1% of the population. The core symptoms used to diagnose ASD are decreased social interaction and increased repetitive behaviors. Despite the large number of affected individuals, the precise mechanisms that cause this disorder remain unclear. The identification of genes and environmental factors associated with ASD allows the study of the underlying mechanisms in animal models. Although ASD presents as a human disorder, based on recent advances in understanding their brain anatomy, physiology, behavior, and evolutionary conservation of neuronal cell types, I propose that zebrafish may provide novel insights into the etiology.
自闭症谱系障碍（ASD）是世界上最常见的遗传性神经精神疾病之一，几乎影响到 1%的人口。用于诊断 ASD 的核心症状是社交互动减少和重复行为增加。尽管受影响的个体数量众多，但导致这种疾病的确切机制仍不清楚。鉴定与 ASD 相关的基因和环境因素可以使我们在动物模型中研究潜在的发病机制。虽然 ASD 表现为一种人类疾病，但基于近年来对其大脑解剖结构、生理学、行为和神经元细胞类型进化保守性的理解，我提出斑马鱼可能为发病机制提供新的见解。
