Rosati Luigi, Chianese Teresa, Mileo Aldo, De Falco Maria, Capaldo Anna
Department of Biology, University Federico II, Via Cinthia 21, 80126 Naples, Italy.
Centro Interdipartimentale di Ricerca "Ambiente" (CIRAM), University Federico II, 80134 Naples, Italy.
Vet Sci. 2023 Jul 25;10(8):484. doi: 10.3390/vetsci10080484.
Cocaine is one of the most widely used drugs that, due to its molecular properties, causes various behavioral alterations, including sexual behavior. In vivo and in vitro studies conducted mainly in mammals have shown various disorders of sexual activity and morpho-functional dysfunctions of the gonads in both sexes. Although the modalities are still unclear, cocaine has been shown to alter the cell cycle, induce apoptosis, and alter sperm motility. In females, this drug alters the formation of the meiotic spindle as well as may obstruct the ovulation mechanism of mature oocytes. The data provided in this review, in addition to reviewing the current literature on the main effects of cocaine on spermatogenesis and oogenesis mainly in mammals, will hopefully provide a basic overview that may help and support further future studies on the molecular interaction of cocaine and its metabolites with germ cells.
可卡因是使用最为广泛的毒品之一，因其分子特性，会引发包括性行为在内的各种行为改变。主要在哺乳动物身上进行的体内和体外研究表明，两性的性活动均出现了各种紊乱，性腺也出现了形态功能障碍。尽管具体方式仍不明确，但已证实可卡因会改变细胞周期、诱导细胞凋亡并改变精子活力。在雌性动物中，这种药物会改变减数分裂纺锤体的形成，还可能阻碍成熟卵母细胞的排卵机制。本综述提供的数据，除了回顾当前关于可卡因主要对哺乳动物精子发生和卵子发生的主要影响的文献外，有望提供一个基本概述，可能有助于并支持未来进一步研究可卡因及其代谢产物与生殖细胞的分子相互作用。
