离体麦醇溶蛋白刺激肠道细胞。
Ex vivo gliadin stimulation of intestinal cells.
机构信息
Department of Chemistry, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL, United States; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, United States; Howard Hughes Medical Institute, University of Chicago, Chicago, IL, United States.
Department of Chemistry, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL, United States; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, United States; Howard Hughes Medical Institute, University of Chicago, Chicago, IL, United States.
出版信息
Methods Cell Biol. 2023;179:13-20. doi: 10.1016/bs.mcb.2022.09.018. Epub 2022 Oct 27.
Celiac disease is an autoimmune response to gluten proteins. While causes for celiac disease have been identified, there is no effective treatment other than diet control. In vitro models for celiac disease are important for quickly gaining understanding of the disease mechanism and testing potential treatments. Here we describe an ex vivo stimulation of intestinal epithelial cells with gliadin peptides as a method to induce celiac disease features in vitro.
乳糜泻是一种针对谷蛋白的自身免疫反应。虽然已经确定了乳糜泻的病因，但除了饮食控制外，尚无有效的治疗方法。乳糜泻的体外模型对于快速了解疾病机制和测试潜在治疗方法非常重要。在这里，我们描述了一种用麦胶肽体外刺激肠上皮细胞的方法，以诱导体外乳糜泻特征。
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