成纤维细胞生长因子4（FGF4）可缓解糖尿病和肥胖症中的高血糖症。

FGF4 alleviates hyperglycemia in diabetes and obesity conditions.

作者信息

Sundaram Sivaraj M, Lenin Raji Rajesh, Janardhanan Rajiv

机构信息

Division of Medical Research, Faculty of Medical and Health Sciences, SRM Institute of Science and Technology, Kattankulathur 603 203, Chengalpattu District, Tamil Nadu, India.

出版信息

Trends Endocrinol Metab. 2023 Oct;34(10):583-585. doi: 10.1016/j.tem.2023.08.004. Epub 2023 Aug 23.

DOI:10.1016/j.tem.2023.08.004

PMID:37625920

Abstract

Increasing evidence suggests that the brain plays a key role in glucose homeostasis, making it a potential target for the treatment of type 2 diabetes (T2D). Sun et al. recently reported that intracerebroventricular (ICV) administration of a single dose of fibroblast growth factor 4 (FGF4) can induce sustained T2D remission in mouse models in the absence of any risk of hypoglycemia.

摘要

越来越多的证据表明，大脑在葡萄糖稳态中起关键作用，使其成为治疗2型糖尿病（T2D）的潜在靶点。孙等人最近报告称，在小鼠模型中，脑室内（ICV）单次注射成纤维细胞生长因子4（FGF4）可诱导T2D持续缓解，且不存在任何低血糖风险。