Department of Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan.
Eijinkai Seeds Clinic, Tokorozawa, Saitama, Japan.
Jpn J Clin Oncol. 2023 Dec 7;53(12):1130-1137. doi: 10.1093/jjco/hyad115.
The relationship between retention index calculated from dual-time point 18F-fluorodeoxyglucose positron emission tomography-computed tomography and oesophageal cancer prognosis remains unknown. This study aimed to determine usefulness of retention index as a predictor of long-term prognosis of oesophageal cancer and neoadjuvant chemotherapy efficacy.
A total of 151 patients with oesophageal cancer who underwent esophagectomy were evaluated retrospectively in this study. We acquired positron emission tomography scans 60 and 120 min (SUVmax1 and SUVmax2, respectively) after the intravenous administration of 3.7 Mbq/kg 18F-fluorodeoxyglucose. The patients were divided into two groups: high-retention index (retention index ≥29%, 107 patients) and low-retention index (retention index <29%, 44 patients). Retention index was calculated as follows: retention index (%) = [(SUVmax2 - SUVmax1)/SUVmax1] × 100.
The overall survival and relapse-free survival rates in the high-retention index group were significantly lower than those in the low-retention index group (P < 0.001). Our multivariate analysis identified that the high-retention index group contained independent risk factors for overall survival (hazard ratio: 2.44, P = 0.009) and relapse-free survival (hazard ratio: 2.61, P = 0.002). The high-retention index group exhibited a lower partial response rate to neoadjuvant chemotherapy evaluated by computed tomography (P < 0.001) and a lower pathological therapeutic effect in the resected specimen (P = 0.019) than the low-retention index group.
The retention index was associated with neoadjuvant chemotherapy responses and long-term prognosis for oesophageal cancer.
双时相 18F-氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描计算的滞留指数与食管癌预后之间的关系尚不清楚。本研究旨在确定滞留指数作为食管癌和新辅助化疗疗效长期预后预测因子的有用性。
本研究回顾性评估了 151 例接受食管癌切除术的患者。我们在静脉注射 3.7 MBq/kg 18F-氟代脱氧葡萄糖后 60 分钟和 120 分钟（分别为 SUVmax1 和 SUVmax2）获得正电子发射断层扫描。患者分为两组：高保留指数（保留指数≥29%，107 例）和低保留指数（保留指数<29%，44 例）。保留指数的计算方法如下：保留指数（%）= [(SUVmax2-SUVmax1)/SUVmax1]×100。
高保留指数组的总生存率和无复发生存率明显低于低保留指数组（P<0.001）。我们的多变量分析确定，高保留指数组是总生存率（危险比：2.44，P=0.009）和无复发生存率（危险比：2.61，P=0.002）的独立危险因素。高保留指数组的新辅助化疗疗效评估计算机断层扫描（P<0.001）和切除标本的病理治疗效果（P=0.019）低于低保留指数组。
保留指数与新辅助化疗反应和食管癌的长期预后相关。
