Doad Jagroop, Gupta Nithin, Leavitt Lydia, Hart Alexandra, Nguyen Andrew, Kaura Shawn, DeStefano Frank, McCray Edwin, Lucke-Wold Brandon
Leon Levine Hall of Medical Sciences, School of Osteopathic Medicine, Campbell University, 4350 US Hwy 421 S, Lillington, NC 27546, USA.
College of Medicine, University of Illinois, 1601 Parkview Ave., Rockford, IL 61107, USA.
Biomedicines. 2023 Aug 3;11(8):2185. doi: 10.3390/biomedicines11082185.
With the incidence of central and peripheral nervous system disorders on the rise, neurosurgical procedures paired with the careful administration of select medications have become necessary to optimize patient outcomes. Despite efforts to decrease the over-prescription of common addictive drugs, such as opioids, prescription costs continue to rise. This study analyzed temporal trends in medication use and cost for spinal fusion and brain tumor resection procedures. The Medicare Part B Database was queried from 2016 to 2020 for data regarding spinal fusion and brain tumor resection procedures, while the Part D Database was used to extract data for two commonly prescribed medications for each procedure. Pearson's correlation coefficient and linear regression were completed for the analyzed variables. The results showed a significant negative correlation between the number of spinal procedure beneficiaries and the cost of methocarbamol, as well as between the annual percent change in spinal beneficiaries and the annual percent change in oxycodone cost. Linear regression revealed that oxycodone cost was the only parameter with a statistically significant model. Moving forward, it is imperative to combat rising drug costs, regardless of trends seen in their usage. Further studies should focus on the utilization of primary data in a multi-center study.
随着中枢和外周神经系统疾病的发病率不断上升，神经外科手术与精心选用特定药物的联合使用对于优化患者治疗效果已变得必不可少。尽管人们努力减少阿片类等常见成瘾药物的过度处方，但处方费用仍在持续上涨。本研究分析了脊柱融合术和脑肿瘤切除术的用药情况及费用的时间趋势。查询了医疗保险B部分数据库2016年至2020年期间有关脊柱融合术和脑肿瘤切除术的数据，同时利用D部分数据库提取每种手术两种常用处方药的数据。对分析变量完成了Pearson相关系数和线性回归分析。结果显示，脊柱手术受益人数与美索巴莫费用之间、脊柱受益人的年度百分比变化与羟考酮费用的年度百分比变化之间存在显著负相关。线性回归分析表明，羟考酮费用是唯一具有统计学显著模型的参数。展望未来，无论药物使用趋势如何，应对不断上涨的药物费用势在必行。进一步的研究应侧重于在多中心研究中利用原始数据。
