Klein Maurice, Wefers Merle, Hallermann Christian, Fischer Henrike J, Hölzle Frank, Wermker Kai
Department of Oral, Maxillofacial and Facial Plastic Surgery, School of Medicine, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.
Orthodontics Meyer, Kurze Straße 6, 48151 Muenster, Germany.
Cancers (Basel). 2023 Aug 14;15(16):4087. doi: 10.3390/cancers15164087.
High IMP3 expression is correlated with a worse outcome. Until now, there have been no data about IMP3 expression and clinical outcome for high-risk localisation of squamous cell carcinoma of the skin (cSCC).
One-hundred twenty-two patients with cSCC of the lip and ear were included, and IMP3 expression in the tumours was immunohistochemically assessed in different evaluation approaches. Subsequently, subgroups were analysed in a matched pair approach and correlated with clinical pathologic parameters. In the following, different IMP3 analysis methods were tested for clinical suitability.
We found a significant correlation between IMP3 expression and risk for lymph node metastasis, local relapse, and progression-free survival.
On basis of our data, we suggest a prognostic benefit cutoff value for high (>50%) and low (<50%) IMP3 expression. Thus, IMP3 expression has a high scientific potential for further studies and could potentially be used as a prognostic marker in diagnostic and therapeutic decision-making.
IMP3高表达与较差的预后相关。迄今为止，尚无关于皮肤鳞状细胞癌（cSCC）高危部位IMP3表达与临床预后的数据。
纳入122例唇部和耳部cSCC患者，采用不同评估方法对肿瘤中的IMP3表达进行免疫组织化学评估。随后，采用配对方法分析亚组，并与临床病理参数进行关联。接下来，测试不同的IMP3分析方法在临床上的适用性。
我们发现IMP3表达与淋巴结转移风险、局部复发及无进展生存期之间存在显著相关性。
根据我们的数据，我们提出IMP3高表达（>50%）和低表达（<50%）的预后获益临界值。因此，IMP3表达在进一步研究中具有很高的科学潜力，并有可能在诊断和治疗决策中用作预后标志物。
