Weis Ezekiel, Jiang Jing, Skalet Alison H, Shields Carol L, Crump R Trafford
Department of Surgery, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
Departments of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA.
Cancers (Basel). 2023 Aug 17;15(16):4142. doi: 10.3390/cancers15164142.
The objective of this study was to evaluate the psychometric properties of a new patient-reported outcome instrument intended for use with patients who have undergone brachytherapy for uveal melanoma (PROM-UM). Classical test theory and item response theory were used to evaluate the performance of individual items and domains. A convenience sample of 439 participants who had undergone brachytherapy for uveal melanoma from one of three North American ocular oncology treatment centers were included in this cross-sectional study. Exploratory factor analysis identified three domains which were labelled "Symptom Impairment", "Worry", and "Discomfort". The acceptability of the instrument was supported by little missing data (range = 0.00-1.14%) and low maximum endorsement (range = 0.00-1.82%). Item-total (range = 0.68-0.85) and inter-item (range = 0.74-0.80) correlations indicated acceptable reliability. Discrimination and difficulty were assessed using item response theory. Items in all three domains indicated moderate to very high discrimination (range = 1.00-4.10). Two items in the Symptom Impairment domain were too difficult to measure. Response ranges in the other two domains demonstrated acceptable difficulty. These results from the study indicate that this new patient-reported outcome instrument can be used with patients treated with brachytherapy for uveal melanoma. Providers could use this instrument to help inform post-treatment management.
本研究的目的是评估一种新的患者报告结局工具（用于接受葡萄膜黑色素瘤近距离放射治疗的患者，即PROM-UM）的心理测量特性。采用经典测试理论和项目反应理论来评估各个项目和领域的表现。本横断面研究纳入了来自北美三个眼部肿瘤治疗中心之一、接受过葡萄膜黑色素瘤近距离放射治疗的439名参与者的便利样本。探索性因素分析确定了三个领域，分别标记为“症状损害”、“担忧”和“不适”。缺失数据极少（范围 = 0.00 - 1.14%）且最高认可率较低（范围 = 0.00 - 1.82%），这支持了该工具的可接受性。项目与总分的相关性（范围 = 0.68 - 0.85）以及项目间的相关性（范围 = 0.74 - 0.80）表明可靠性可接受。使用项目反应理论评估区分度和难度。所有三个领域的项目均显示出中等至非常高的区分度（范围 = 1.00 - 4.10）。症状损害领域的两个项目测量难度过大。其他两个领域的反应范围显示难度可接受。该研究的这些结果表明，这种新的患者报告结局工具可用于接受葡萄膜黑色素瘤近距离放射治疗的患者。医疗服务提供者可以使用该工具来为治疗后管理提供信息。
