Ferré-Dolcet Lluis, Bordogna Matteo, Contiero Barbara, Fontaine Christelle, Bedin Silvia, Romagnoli Stefano
Department of Animal Medicine, Production and Health, University of Padova, 35122 Padova, Italy.
Altinia Veterinary Clinic, 30173 Venice, Italy.
Animals (Basel). 2023 Aug 8;13(16):2552. doi: 10.3390/ani13162552.
Deslorelin implant use in cats is a medical alternative to surgical sterilization, and due to its prolonged efficacy, its use has shown growing interest in the veterinary community. In the case of breeding facilities, its removal is often requested for the early restoration of testicular function. As anti-Müllerian hormones (AMH) in males is dependent of testosterone secretion, its assay may determine the restoration of testicular steroid secretion. An average of 3 weeks has been already described for tomcats' testicular function resumption after implant removal, but information about AMH concentrations in deslorelin-treated tomcats is lacking. Fourteen tomcats were treated for temporary suppression of fertility with a 4.7 mg deslorelin implant, which was surgically removed after 3, 6 or 9 months (n = 6, 4 and 4 tomcats, respectively). A general clinical and reproductive check with a gonadorelin stimulation test for testosterone determination was performed before deslorelin implant administration. After implant removal, tomcats' testicles were ultrasonographically checked for volume determination every 1-2 weeks with observation of the glans penis (presence or absence of spikes) and blood collection to assay both testosterone and AMH concentrations. AMH concentrations increased significantly during the deslorelin treatment from 20.95 ± 4.97 ng/mL to 82.41 ± 14.59 ng/mL ( < 0.05). Following implant removal, AMH concentrations progressively decreased to pre-treatment levels, with a value of 28.42 ± 7.98 ng/mL on the third week post-removal where testosterone secretion was again detected. Even if a big variability of AMH concentrations exists between male individuals, resumption of tomcats' testicular function following a deslorelin treatment can be determined by AMH assay.
在猫中使用地洛瑞林植入物是手术绝育的一种医学替代方法，由于其疗效持久，它在兽医界的应用越来越受到关注。在繁殖场所的情况下，通常要求移除该植入物以尽早恢复睾丸功能。由于雄性体内抗苗勒管激素（AMH）依赖于睾酮分泌，其检测可确定睾丸类固醇分泌的恢复情况。已经有报道称，移除植入物后雄猫的睾丸功能恢复平均需要3周时间，但关于接受地洛瑞林治疗的雄猫体内AMH浓度的信息尚缺。14只雄猫接受了4.7毫克地洛瑞林植入物治疗以暂时抑制生育能力，在3、6或9个月后手术移除植入物（分别为6只、4只和4只雄猫）。在地洛瑞林植入物给药前，进行了全面的临床和生殖检查，并通过促性腺激素释放激素刺激试验测定睾酮。移除植入物后，每1 - 2周对雄猫的睾丸进行超声检查以测定体积，观察阴茎头（有无尖刺），并采集血液以检测睾酮和AMH浓度。在地洛瑞林治疗期间，AMH浓度从20.95±4.97纳克/毫升显著增加至82.41±14.59纳克/毫升（<0.05）。移除植入物后，AMH浓度逐渐降至治疗前水平，在移除后第三周时为28.42±7.98纳克/毫升，此时再次检测到睾酮分泌。即使雄性个体之间AMH浓度存在很大差异，但通过AMH检测仍可确定地洛瑞林治疗后雄猫睾丸功能的恢复情况。
