Assawarachan Sathidpak Nantasanti, Ongvisespaibool Thodsapol, Hakhen Benjang, Chuchalermporn Piyathip, Maneesaay Phudit, Thengchaisri Naris
Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.
Endocrinology and Gastroenterology Unit, Kasetsart University Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.
Animals (Basel). 2023 Aug 20;13(16):2677. doi: 10.3390/ani13162677.
Long-term outcomes and survival predictors for different clinicopathologies (idiopathic chronic hepatitis, liver fibrosis, vacuolar hepatopathy) in dogs with hepatobiliary diseases are poorly described. In this study, ninety dogs were followed up for up to five years to investigate clinical factors that predict two-year survival in canine patients after liver biopsy. Univariate and multivariate analyses were performed based on clinical and laboratory data to determine the association between clinical and laboratory data and mortality rates. Overall, the one-, two-, and five-year mortality rates were 28.9%, 45.6%, and 78.9%, respectively. Univariate analysis indicated that male gender, ascites, elevated serum gamma-glutamyl transpeptidase (GGT), hypercholesterolemia, hypoalbuminemia, prolonged activated partial thromboplastin clotting time (aPTT), and prolonged thrombin clotting time (TT) were associated with an increased two-year mortality rate. Results from multivariate analysis demonstrated a significant association between male gender ( = 0.022), elevated serum GGT ( < 0.001), hypoalbuminemia ( < 0.001), and prolonged aPTT ( < 0.001) and an increased two-year mortality rate, regardless of the specific type of liver pathology. Elevated GGT was associated with the highest risk for increased two-year mortality (95% CI: hazard ratio 6.02-41.21). In conclusion, various clinical factors in dogs with liver diseases are useful for prognosis prediction.
对于患有肝胆疾病的犬类，不同临床病理类型（特发性慢性肝炎、肝纤维化、空泡性肝病）的长期预后和生存预测因素描述甚少。在本研究中，对90只犬进行了长达五年的随访，以调查肝活检后犬类患者两年生存的临床预测因素。基于临床和实验室数据进行单变量和多变量分析，以确定临床和实验室数据与死亡率之间的关联。总体而言，一年、两年和五年死亡率分别为28.9%、45.6%和78.9%。单变量分析表明，雄性、腹水、血清γ-谷氨酰转肽酶（GGT）升高、高胆固醇血症、低白蛋白血症、活化部分凝血活酶凝血时间（aPTT）延长和凝血酶凝血时间（TT）延长与两年死亡率增加相关。多变量分析结果显示，无论肝脏病理的具体类型如何，雄性（P = 0.022）、血清GGT升高（P < 0.001）、低白蛋白血症（P < 0.001）和aPTT延长（P < 0.001）与两年死亡率增加之间存在显著关联。GGT升高与两年死亡率增加的风险最高相关（95%CI：风险比6.02 - 41.21）。总之，患有肝脏疾病犬类的各种临床因素对预后预测有用。
