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[未成熟大鼠脊髓孤立灌流节段神经元对血管灌流肢体伤害性刺激的反应]

[Reactions of neurons of an isolated superfused segment of spinal cord in the immature rat to nociceptive stimulation of an vessel-perfused extremity].

作者信息

Khasabov S G, Tamarova Z A

出版信息

Neirofiziologiia. 1986;18(4):563-6.

PMID:3762802
Abstract

An in vitro preparation for testing nociceptive neuron responses in 2-3 weeks old rats is described. The preparation consists of isolated superfused spinal segment and intravascularly perfused hind limb connected through the dorsal root. Mechanical (prick, pinch) or chemical (intravascular injection of the algogenic substance) nociceptive stimulation of the hind limb induced an increase in discharge frequency of single neurons.

摘要

本文描述了一种用于测试2-3周龄大鼠伤害性神经元反应的体外制备方法。该制备方法由通过背根连接的孤立的灌注脊髓节段和血管内灌注的后肢组成。对后肢进行机械性(针刺、捏)或化学性(向血管内注射致痛物质)伤害性刺激会导致单个神经元放电频率增加。

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