Kwon Ki-Wook, Lee Young-Hyeon, Yeo Min-Ho, Park Sang-Hyun, Kim Hye-Ran, Kim Hye-Sook, Chang Kyung-Soo
Department of Clinical Laboratory Science, Catholic University of Pusan, Busan 46252, Republic of Korea.
Department of Clinical Laboratory Science, Kyungnam College of Information & Technology, Busan 47011, Republic of Korea.
Healthcare (Basel). 2023 Aug 17;11(16):2325. doi: 10.3390/healthcare11162325.
Most (90%) vitamin D synthesis occurs in the skin using sunlight (ultraviolet rays), and 10% is obtained through food. Vitamin D is an essential nutrient for skeletal growth and maintenance, cell proliferation and differentiation, and immune function. This study investigated whether maternal serum vitamin D concentrations induce maternofetal effects. Hematological analysis, serological changes, and precision fetal ultrasound findings were analyzed by maternal vitamin D concentration in gestational weeks 22-25 to ascertain direct effects on fetal growth. Bone density-vitamin D concentration correlation was analyzed. No hematologic or serological effect of maternal vitamin D concentration was detected; however, the sexually transmitted infection and cross-infection rates were inversely proportional to maternal vitamin D concentration. No significant correlation between vitamin D concentration and vertebral and femoral BMD was detected. For fetal growth, biparietal diameter, head circumference, abdominal circumference, femur length, and humerus length were analyzed. Humerus ( < 0.05) and femur ( < 0.001) lengths were higher in the vitamin D-sufficient group than in the vitamin D-deficient group. Vitamin D concentration did not positively affect hematologic changes and bone density; maternal vitamin D concentration essentially affected fetal bone growth. Vitamin D inhibits sexually transmitted infections in mothers and promotes fetal bone growth. Prevention of vitamin D deficiency, supplementation, or outdoor activities is recommended.
大多数（90%）的维生素D合成是在皮肤中利用阳光（紫外线）进行的，10%通过食物获取。维生素D是骨骼生长与维持、细胞增殖与分化以及免疫功能所必需的营养素。本研究调查了母体血清维生素D浓度是否会产生母胎效应。在妊娠第22 - 25周，通过母体维生素D浓度分析血液学指标、血清学变化以及精确的胎儿超声检查结果，以确定对胎儿生长发育的直接影响。分析了骨密度与维生素D浓度的相关性。未检测到母体维生素D浓度对血液学或血清学的影响；然而，性传播感染率和交叉感染率与母体维生素D浓度呈负相关。未检测到维生素D浓度与脊柱和股骨骨密度之间存在显著相关性。对于胎儿生长发育，分析了双顶径、头围、腹围、股骨长度和肱骨长度。维生素D充足组的肱骨长度（<0.05）和股骨长度（<0.001）高于维生素D缺乏组。维生素D浓度对血液学变化和骨密度没有积极影响；母体维生素D浓度主要影响胎儿骨骼生长。维生素D可抑制母亲的性传播感染并促进胎儿骨骼生长。建议预防维生素D缺乏、进行补充或户外活动。
