Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, 56126 Pisa, Italy.
Department of Psychology & Behavioral Neuroscience, Randolph-Macon College, Ashland, VA 23005, USA.
Genes (Basel). 2023 Jul 29;14(8):1558. doi: 10.3390/genes14081558.
Prostate cancer (PC) is polygenic disease involving many genes, and more importantly a host of gene-gene interactions, including transcriptional factors. The gene is a transcriptional target of numerous oncoproteins, and its dysregulation can contribute to tumor progression by abnormal activation of targeted oncogenes. Using data from the Cancer Genome Atlas, we tested the possible involvement of in PC progression. A multi-dimensional scaling (MDS) model was applied to clarify the association of expression with other key genes, such as , , ( and ), , and . An increased expression was associated with higher PC grades and with a worse prognosis. It was also positively related to , , and . Moreover, MDS showed the central role of in influencing the other target genes by its central location on the map. Our study is the first to show a link between expression and other genes involved in PC progression, suggesting a novel role for in PC progression. This network between and through may have an important role in PC progression, as suggested by the association between high expression and unfavorable prognosis in our analysis.
前列腺癌（PC）是一种涉及多种基因的多基因疾病，更重要的是涉及许多基因-基因相互作用，包括转录因子。该基因是许多癌蛋白的转录靶标，其失调可通过靶向癌基因的异常激活导致肿瘤进展。使用来自癌症基因组图谱的数据，我们测试了 在 PC 进展中的可能参与。多维缩放（MDS）模型用于阐明 表达与其他关键基因（如 、 、 （和 ）、 、 和 ）的关联。表达增加与较高的 PC 分级和较差的预后相关。它也与 、 和 呈正相关。此外，MDS 显示 在通过其在图谱上的中心位置影响其他靶基因方面的核心作用。我们的研究首次表明 表达与参与 PC 进展的其他基因之间存在联系，提示 在 PC 进展中具有新的作用。通过 ， 和 之间的这种网络可能在 PC 进展中具有重要作用，正如我们的分析中高 表达与不利预后之间的关联所表明的那样。
