Genetic Association between Inflammatory-Related Polymorphism in , , , and Idiopathic Recurrent Implantation Failure.

Recurrent implantation failure (RIF) is defined as a failure to achieve pregnancy after multiple embryo transfers. Implantation is closely related to inflammatory gradients, and interleukin-1beta (IL-1β), IL-6, and tumor necrosis factor-alpha (TNF-α) play a key role in maternal and trophoblast inflammation during implantation. Signal transducer and activator of transcription 3 (STAT3) interacts with cytokines and plays a critical role in implantation through involvement in the inflammation of the embryo and placenta. Therefore, we investigated 151 RIF patients and 321 healthy controls in Korea and analyzed the association between the polymorphisms ( rs1053004, rs16944, rs1800796, and rs1800629, 1800630) and RIF prevalence. In this paper, we identified that rs1053004 (AG, adjusted odds rate [AOR] = 0.623; = 0.027; GG, AOR = 0.513; = 0.043; Dominant, AOR = 0.601, = 0.011), rs1800796 (GG, AOR = 2.472; = 0.032; Recessive, AOR = 2.374, = 0.037), and rs1800629 (GA, AOR = 2.127, = 0.010, Dominant, AOR = 2.198, = 0.007) have a significant association with RIF prevalence. This study is the first to investigate the association of each polymorphism with RIF prevalence in Korea and to compare their effect based on their function on inflammation.