Department of Biomedical Science, College of Life Science, CHA University, Seongnam 13496, Republic of Korea.
Department of Obstetrics and Gynecology, CHA Bundang Medical Center, School of Medicine, CHA University, Seongnam 13496, Republic of Korea.
Genes (Basel). 2023 Aug 5;14(8):1588. doi: 10.3390/genes14081588.
Recurrent implantation failure (RIF) is defined as a failure to achieve pregnancy after multiple embryo transfers. Implantation is closely related to inflammatory gradients, and interleukin-1beta (IL-1β), IL-6, and tumor necrosis factor-alpha (TNF-α) play a key role in maternal and trophoblast inflammation during implantation. Signal transducer and activator of transcription 3 (STAT3) interacts with cytokines and plays a critical role in implantation through involvement in the inflammation of the embryo and placenta. Therefore, we investigated 151 RIF patients and 321 healthy controls in Korea and analyzed the association between the polymorphisms ( rs1053004, rs16944, rs1800796, and rs1800629, 1800630) and RIF prevalence. In this paper, we identified that rs1053004 (AG, adjusted odds rate [AOR] = 0.623; = 0.027; GG, AOR = 0.513; = 0.043; Dominant, AOR = 0.601, = 0.011), rs1800796 (GG, AOR = 2.472; = 0.032; Recessive, AOR = 2.374, = 0.037), and rs1800629 (GA, AOR = 2.127, = 0.010, Dominant, AOR = 2.198, = 0.007) have a significant association with RIF prevalence. This study is the first to investigate the association of each polymorphism with RIF prevalence in Korea and to compare their effect based on their function on inflammation.
反复着床失败（RIF）定义为多次胚胎移植后未能妊娠。着床与炎症梯度密切相关，白细胞介素-1β（IL-1β）、IL-6 和肿瘤坏死因子-α（TNF-α）在着床期间母体和滋养层炎症中发挥关键作用。信号转导和转录激活因子 3（STAT3）与细胞因子相互作用，通过参与胚胎和胎盘炎症在着床中发挥关键作用。因此，我们在韩国调查了 151 名 RIF 患者和 321 名健康对照者，并分析了这些多态性（rs1053004、rs16944、rs1800796 和 rs1800629、rs1800630）与 RIF 发生率之间的关联。在本研究中，我们发现 rs1053004（AG，调整优势比 [AOR] = 0.623； = 0.027；GG，AOR = 0.513； = 0.043；显性，AOR = 0.601， = 0.011）、rs1800796（GG，AOR = 2.472； = 0.032；隐性，AOR = 2.374， = 0.037）和 rs1800629（GA，AOR = 2.127， = 0.010，显性，AOR = 2.198， = 0.007）与 RIF 发生率有显著关联。本研究首次在韩国调查了每个多态性与 RIF 发生率的相关性，并根据其在炎症中的功能比较了它们的影响。
