Common Variants in One-Carbon Metabolism Genes (, , ) and Depression in Gynecologic Cancers.

We investigated the association between methylenetetrahydrofolate reductase (gene 677C>T, rs1801133), 5-methyltetrahydrofolate-homocysteine methyltransferase ( 2756A>G, rs1805087), and methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 (gene 1958G>A, rs2236225)-well-studied functional variants involved in one-carbon metabolism-and gynecologic cancer risk, and the interaction between these polymorphisms and depression. A total of 200 gynecologic cancer cases and 240 healthy controls were recruited to participate in this study. Three single-nucleotide variants (SNVs) (rs1801133, rs1805087, rs2236225) were genotyped using the PCR-restriction fragment length polymorphism method. Depression was assessed in all patients using the Hamilton Depression Scale. Depression was statistically significantly more frequent in women with gynecologic cancers (69.5% vs. 34.2% in controls, < 0.001). rs2236225 was associated with an increased risk of gynecologic cancers (in dominant OR = 1.53, = 0.033, and in log-additive models OR = 1.37, = 0.024). Moreover, an association was found between depression risk and rs1801133 genotypes in the controls but not in women with gynecologic cancers (in codominant model CC vs. TT: OR = 3.39, 95%: 1.49-7.74, = 0.011). Cancers of the female reproductive system are associated with the occurrence of depression, and ovarian cancer may be associated with the rs2236225 variant of the gene. In addition, in healthy aging women in the Polish population, the rs1801133 variant of the gene is associated with depression.