Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.
Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.
Front Immunol. 2022 Oct 5;13:1032294. doi: 10.3389/fimmu.2022.1032294. eCollection 2022.
Advances in the understanding of psychoneuroimmunology in the past decade have emphasized the notion that stress and cancer are interlinked closely. Durable chronic stress accelerated tumorigenesis and progression, which is unfavorable for clinical outcomes of cancer patients. Available evidence has provided unprecedented knowledge about the role and mechanisms of chronic stress in carcinogenesis, the most well-known one is dysfunction of the hypothalamus-pituitary-adrenal (HPA) axis and the sympathetic nervous system (SNS). With abnormal activation of neuroendocrine system, stress-related hormones contribute to increased oncogenes expression, exacerbated chronic inflammation and impaired immunologic function. In addition, accumulating studies have demonstrated that diverse stress interventions including pharmacological approaches, physical exercises and psychological relaxation have been administered to assist in mental disorders reduction and life quality improvement in cancer patients. In this review, we systematically summarize the connection and mechanisms in the stress-immune-cancer axis identified by animal and clinical studies, as well as conclude the effectiveness and deficiencies of existing stress management strategies.
在过去十年中，对心理神经免疫学的理解取得了进展，强调了压力和癌症密切相关的观点。持久的慢性压力会加速肿瘤的发生和发展，这不利于癌症患者的临床结局。现有证据提供了关于慢性压力在致癌作用中的作用和机制的前所未有的知识，其中最著名的是下丘脑-垂体-肾上腺 (HPA) 轴和交感神经系统 (SNS) 的功能障碍。神经内分泌系统的异常激活导致应激相关激素增加癌基因表达、加剧慢性炎症和损害免疫功能。此外，越来越多的研究表明，包括药物治疗、体育锻炼和心理放松在内的各种应激干预措施已被用于辅助减少癌症患者的精神障碍和提高生活质量。在这篇综述中，我们系统地总结了动物和临床研究中确定的应激-免疫-癌症轴的联系和机制，并总结了现有应激管理策略的有效性和不足。
