Department of Hand, Plastic and Reconstructive Surgery, Burn Center, Department of Plastic and Hand Surgery, University of Heidelberg, BG Trauma Hospital, D-67071 Ludwigshafen, Germany.
Neuroscience and Mental Health Program, SickKids Research Institute, Toronto, ON M5G 1X8, Canada.
Int J Mol Sci. 2023 Aug 14;24(16):12771. doi: 10.3390/ijms241612771.
Peripheral nerve injuries have far-reaching implications for individuals and society, leading to functional impairments, prolonged rehabilitation, and substantial socioeconomic burdens. Tacrolimus, a potent immunosuppressive drug known for its neuroregenerative properties, has emerged in experimental studies as a promising candidate to accelerate nerve fiber regeneration. This review investigates the therapeutic potential of tacrolimus by exploring the postulated mechanisms of action in relation to biological barriers to nerve injury recovery. By mapping both the preclinical and clinical evidence, the benefits and drawbacks of systemic tacrolimus administration and novel delivery systems for localized tacrolimus delivery after nerve injury are elucidated. Through synthesizing the current evidence, identifying practical barriers for clinical translation, and discussing potential strategies to overcome the translational gap, this review provides insights into the translational perspectives of tacrolimus as an adjunct therapy for nerve regeneration.
周围神经损伤对个人和社会都有深远的影响，导致功能障碍、康复时间延长和巨大的社会经济负担。他克莫司是一种具有神经再生特性的强效免疫抑制剂，在实验研究中已被证明是一种有前途的促进神经纤维再生的候选药物。本综述通过探讨与神经损伤恢复相关的生物屏障相关的假定作用机制，研究了他克莫司的治疗潜力。通过绘制临床前和临床证据图谱，阐明了全身性他克莫司给药和神经损伤后局部他克莫司给药的新型传递系统的益处和缺点。通过综合现有证据、确定临床转化的实际障碍以及讨论克服转化差距的潜在策略，本综述深入探讨了他克莫司作为神经再生辅助治疗的转化观点。
