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牙髓间充质干细胞多能性和分化的分子调控机制。

The Molecular Regulatory Mechanism in Multipotency and Differentiation of Wharton's Jelly Stem Cells.

机构信息

The State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, China.

出版信息

Int J Mol Sci. 2023 Aug 18;24(16):12909. doi: 10.3390/ijms241612909.

DOI:10.3390/ijms241612909
PMID:37629090
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10454700/
Abstract

Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) are isolated from Wharton's jelly tissue of umbilical cords. They possess the ability to differentiate into lineage cells of three germ layers. WJ-MSCs have robust proliferative ability and strong immune modulation capacity. They can be easily collected and there are no ethical problems associated with their use. Therefore, WJ-MSCs have great tissue engineering value and clinical application prospects. The identity and functions of WJ-MSCs are regulated by multiple interrelated regulatory mechanisms, including transcriptional regulation and epigenetic modifications. In this article, we summarize the latest research progress on the genetic/epigenetic regulation mechanisms and essential signaling pathways that play crucial roles in pluripotency and differentiation of WJ-MSCs.

摘要

华通氏胶来源的间充质干细胞（WJ-MSCs）从脐带的华通氏胶组织中分离得到。它们具有分化为三个胚层谱系细胞的能力。WJ-MSCs 具有强大的增殖能力和强烈的免疫调节能力。它们易于采集，并且使用它们不存在伦理问题。因此，WJ-MSCs 具有巨大的组织工程价值和临床应用前景。WJ-MSCs 的身份和功能受多种相互关联的调控机制的调控，包括转录调控和表观遗传修饰。本文总结了 WJ-MSCs 多能性和分化过程中发挥关键作用的遗传/表观遗传调控机制和关键信号通路的最新研究进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca3b/10454700/33686027782d/ijms-24-12909-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca3b/10454700/39be08734b39/ijms-24-12909-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca3b/10454700/7543fd27f860/ijms-24-12909-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca3b/10454700/6a5b044d6073/ijms-24-12909-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca3b/10454700/33686027782d/ijms-24-12909-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca3b/10454700/39be08734b39/ijms-24-12909-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca3b/10454700/7543fd27f860/ijms-24-12909-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca3b/10454700/6a5b044d6073/ijms-24-12909-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca3b/10454700/33686027782d/ijms-24-12909-g004.jpg

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Survival and Neurogenesis-Promoting Effects of the Co-Overexpression of and Genes on Wharton's Jelly-Derived Mesenchymal Stem Cells.基因和基因共过表达对沃顿胶间充质干细胞的存活及促进神经发生作用
Life (Basel). 2022 Sep 9;12(9):1406. doi: 10.3390/life12091406.
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Collagen Modulates the Biological Characteristics of WJ-MSCs in Basal and Osteoinduced Conditions.
胶原蛋白在基础条件和骨诱导条件下调节脐带间充质干细胞的生物学特性。
Stem Cells Int. 2022 Aug 28;2022:2116367. doi: 10.1155/2022/2116367. eCollection 2022.
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NR2F2 Regulates Cell Proliferation and Immunomodulation in Whartons' Jelly Stem Cells.NR2F2 调控牙髓干细胞的细胞增殖和免疫调节。
Genes (Basel). 2022 Aug 16;13(8):1458. doi: 10.3390/genes13081458.
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MicroRNA-196a-5p overexpression in Wharton's jelly umbilical cord stem cells promotes their osteogenic differentiation and new bone formation in bone defects in the rat calvarium.在牙髓脐带间充质干细胞中过表达 microRNA-196a-5p 促进其在大鼠颅骨骨缺损中的成骨分化和新骨形成。
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