Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk 630090, Russia.
Institute of Molecular Biology and Biophysics, Federal Research Center for Fundamental and Translational Medicine, Novosibirsk 630117, Russia.
Int J Mol Sci. 2023 Aug 21;24(16):13024. doi: 10.3390/ijms241613024.
New coordination compounds of copper(II) with 2,5-bis(ethylthio)-1,3,4-thiadiazole (L) and 2,5-bis(pyridylmethylthio)-1,3,4-thiadiazole (L) with compositions Cu(L)Br, Cu(L)(CN), Cu(L)Cl, and Cu(L)Br were prepared. The complexes were identified and studied by CHN analysis, infrared (IR) spectroscopy, powder X-Ray diffraction (XRD), and static magnetic susceptibility. The crystal structures of Cu(II) complexes with L were determined. The structures of the coordination core of complexes Cu(L)Cl and Cu(L)Br were determined by Extended X-ray absorption fine structure (EXAFS) spectroscopy. Magnetization measurements have revealed various magnetic states in the studied complexes, ranging from an almost ideal paramagnet in Cu(L)Br to alternating-exchange antiferromagnetic chains in Cu(L)(CN), where double dicyanamide bridges provide an unusually strong exchange interaction (J/k ≈ -23.5 K; J/k ≈ -20.2 K) between Cu(II) ions. The cytotoxic activity of copper(II) complexes with L was estimated on the human cell lines of breast adenocarcinoma () and hepatocellular carcinoma ().
合成了一系列含有 2,5-双（乙硫基）-1,3,4-噻二唑（L）和 2,5-双（吡啶甲基硫基）-1,3,4-噻二唑（L）的铜（II）配合物：Cu(L)Br、Cu(L)(CN)、Cu(L)Cl 和 Cu(L)Br。通过元素分析（CHN）、红外光谱（IR）、粉末 X 射线衍射（XRD）和静态磁化率对配合物进行了鉴定和研究。测定了 Cu(II)配合物的晶体结构。通过扩展 X 射线吸收精细结构（EXAFS）光谱确定了配合物 Cu(L)Cl 和 Cu(L)Br 的配位核结构。磁化测量结果表明，在所研究的配合物中存在多种磁态，从 Cu(L)Br 的近乎理想的顺磁体到 Cu(L)(CN)中的交替交换反铁磁链，其中双二氰胺桥提供了铜（II）离子之间异常强的交换相互作用（J/k ≈ -23.5 K；J/k ≈ -20.2 K）。对 L 与铜（II）配合物的人乳腺癌（）和肝癌（）细胞系进行了细胞毒性活性评估。
