Gehlert D R, Speth R C, Wamsley J K
Neuroscience. 1986 Aug;18(4):837-56. doi: 10.1016/0306-4522(86)90104-1.
Angiotensin II receptors have been localized by quantitative autoradiography in the rat central nervous system after labeling with [125I]angiotensin II. A highly discrete distribution of these receptors was found throughout the rat brain. The highest density was seen in regions of the medulla, hypothalamus and circumventricular organs where angiotensin II could potentially produce cardiovascular, dipsogenic and neuroendocrine responses. The distribution of angiotensin II receptors correlates relatively well with the previously reported distribution of angiotensin immunoreactive nerve terminals as well as areas determined by various physiological techniques to be sensitive to angiotensin II. Finally, the anatomical localization of angiotensin II receptor populations has revealed several areas of the brain where the effects of this peptide have not been investigated. Many of these nuclei are involved in the transmission and processing of somatic and visceral sensory information. These results suggest a broader role for the central renin-angiotensin system in modulating several types of sensory input.
在用[125I]血管紧张素II标记后，已通过定量放射自显影法在大鼠中枢神经系统中定位了血管紧张素II受体。在整个大鼠脑中发现了这些受体高度离散的分布。在延髓、下丘脑和室周器官区域观察到最高密度，在这些区域血管紧张素II可能产生心血管、致渴和神经内分泌反应。血管紧张素II受体的分布与先前报道的血管紧张素免疫反应性神经末梢的分布以及通过各种生理技术确定的对血管紧张素II敏感的区域相对较好地相关。最后，血管紧张素II受体群体的解剖定位揭示了大脑中几个尚未研究该肽作用的区域。这些核中的许多都参与躯体和内脏感觉信息的传递和处理。这些结果表明中枢肾素-血管紧张素系统在调节几种类型的感觉输入方面具有更广泛的作用。
