Nandhra Gursharan Kaur, Chaichanavichkij Phakanant, Birch Malcolm, Scott S Mark
National Bowel Research Centre and GI Physiology Unit, Blizard Institute, Centre for Neuroscience, Surgery & Trauma, Queen Mary University of London, London E1 4NS, UK.
Clinical Physics, Barts Health NHS Trust, The Royal London Hospital, London E1 2BL, UK.
J Clin Med. 2023 Aug 13;12(16):5272. doi: 10.3390/jcm12165272.
Ingestible capsule (IC) systems can assess gastrointestinal (GI) transit times as a surrogate for gut motility for extended periods of time within a minimally invasive, radiation-free and ambulatory setting.
A literature review of IC systems and a systematic review of studies utilizing IC systems to measure GI transit times in healthy volunteers was performed. Screening for eligible studies, data extraction and bias assessments was performed by two reviewers. A narrative synthesis of the results was performed.
The literature review identified 23 different IC systems. The systematic review found 6892 records, of which 22 studies were eligible. GI transit time data were available from a total of 1885 healthy volunteers. Overall, seventeen included studies reported gastric emptying time (GET) and small intestinal transit time (SITT). Colonic transit time (CTT) was reported in nine studies and whole gut transit time (WGTT) was reported in eleven studies. GI transit times in the included studies ranged between 0.4 and 15.3 h for GET, 3.3-7 h for SITT, 15.9-28.9 h for CTT and 23.0-37.4 h for WGTT. GI transit times, notably GET, were influenced by the study protocol.
This review provides an up-to-date overview of IC systems and reference ranges for GI transit times. It also highlights the need to standardise protocols to differentiate between normal and pathological function.
可摄入胶囊（IC）系统能够在微创、无辐射且可移动的环境中，长时间评估胃肠道（GI）转运时间，以此作为肠道蠕动的替代指标。
对IC系统进行了文献综述，并对利用IC系统测量健康志愿者GI转运时间的研究进行了系统综述。由两名审阅者进行合格研究的筛选、数据提取和偏倚评估。对结果进行了叙述性综合分析。
文献综述确定了23种不同的IC系统。系统综述共检索到6892条记录，其中22项研究符合要求。共有1885名健康志愿者提供了GI转运时间数据。总体而言，纳入的17项研究报告了胃排空时间（GET）和小肠转运时间（SITT）。9项研究报告了结肠转运时间（CTT），11项研究报告了全肠道转运时间（WGTT）。纳入研究中的GI转运时间范围为：GET为0.4至15.3小时，SITT为3.3至7小时，CTT为15.9至28.9小时，WGTT为23.0至37.4小时。GI转运时间，尤其是GET，受研究方案的影响。
本综述提供了IC系统的最新概述以及GI转运时间的参考范围。它还强调了标准化方案以区分正常和病理功能的必要性。
