Yamaguchi Naoyuki, Sakaguchi Takuki, Isomoto Hajime, Inamine Tatsuo, Ueda Haruka, Fukuda Daisuke, Ohnita Ken, Kanda Tsutomu, Kurumi Hiroki, Matsushima Kayoko, Hirayama Tatsuro, Yashima Kazuo, Tsukamoto Kazuhiro
Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biological Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
Department of Gastroenterology and Nephrology, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago 683-8504, Japan.
J Clin Med. 2023 Aug 19;12(16):5384. doi: 10.3390/jcm12165384.
() infection causes a progression to atrophic gastritis and results in gastric cancer. Cytotoxin-associated gene A (CagA), a major virulence factor of , is injected into gastric epithelial cells using the type IV secretion system. On the other hand, gastric epithelial cells degrade CagA using an autophagy system, which is strictly regulated by the autophagy-related (ATG) genes. This study aimed to identify SNPs in , , , and associated with gastric mucosal atrophy (GMA). Here, two-hundred -positive participants without gastric cancer were included. The degree of GMA was evaluated via the pepsinogen method. Twenty-five SNPs located in the four candidate genes were selected as tag SNPs. The frequency of each SNP between the GMA and the non-GMA group was evaluated. The rs6431655, rs6431659, and rs4663136 in and rs26537 in were independently associated with GMA. Of these four SNPs, the G/G genotype of rs6431659 in has the highest odd ratio (Odds ratio = 3.835, 95% confidence intervals = 1.337-1.005, = 0.008). Further functional analyses and prospective analyses with a larger sample size are required.
（）感染会导致进展为萎缩性胃炎并引发胃癌。细胞毒素相关基因A（CagA）是（）的主要毒力因子，它通过IV型分泌系统注入胃上皮细胞。另一方面，胃上皮细胞利用自噬系统降解CagA，该自噬系统受自噬相关（ATG）基因严格调控。本研究旨在鉴定与胃黏膜萎缩（GMA）相关的（）、（）、（）和（）中的单核苷酸多态性（SNP）。在此，纳入了200名无胃癌的（）阳性参与者。通过胃蛋白酶原法评估GMA的程度。位于四个候选基因中的25个SNP被选为标签SNP。评估了GMA组和非GMA组中每个SNP的频率。（）中的rs6431655、rs6431659和rs4663136以及（）中的rs26537与GMA独立相关。在这四个SNP中，（）中rs6431659的G/G基因型具有最高的优势比（优势比=3.835，95%置信区间=1.337 - 1.005，P = 0.008）。需要进一步进行功能分析和更大样本量的前瞻性分析。
