Yamaguchi Naoyuki, Sakaguchi Takuki, Taira Miki, Fukuda Daisuke, Ohnita Ken, Hirayama Tatsuro, Yashima Kazuo, Isomoto Hajime, Tsukamoto Kazuhiro
Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biological Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
Department of Gastroenterology and Nephrology, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago 683-8504, Japan.
J Clin Med. 2024 Jan 22;13(2):629. doi: 10.3390/jcm13020629.
Cytotoxin-associated gene A (CagA) is an oncoprotein that injects into the host's gastric epithelial cells and that induces proinflammatory cytokines, such as interleukin (IL)-18 and IL-1β. As a result, it leads to atrophic gastritis (AG), a precancerous lesion of gastric cancer. On the other hand, host cells degrade CagA using autophagy systems. However, few studies exist about the single nucleotide polymorphisms (SNPs) in , , , , , , and which belong to the autophagy-related genes concerning AG. This study aimed to detect biomarkers associated with AG. Herein, -positive subjects ( = 200) were divided into the AG ( = 94) and non-AG ( = 106) groups. Thirty tag SNPs were selected from the above seven candidate genes. The SNP frequency between the two groups was analyzed. The frequency of the C/T or T/T genotype at rs4683787 of was significantly lower in the AG group than in the non-AG group ( = 0.034, odds ratio = 0.535). Based on multivariate analysis, the C/C genotype of rs4684787 and age were independently associated with gastric mucosal atrophy. This finding helps stratify the patients needing timely endoscopic screening or early eradication of .
细胞毒素相关基因A（CagA）是一种癌蛋白，可注入宿主胃上皮细胞并诱导促炎细胞因子，如白细胞介素（IL）-18和IL-1β。因此，它会导致萎缩性胃炎（AG），这是胃癌的一种癌前病变。另一方面，宿主细胞利用自噬系统降解CagA。然而，关于与AG相关的自噬相关基因中的单核苷酸多态性（SNP），如 、 、 、 、 、 和 的研究很少。本研究旨在检测与AG相关的生物标志物。在此，CagA阳性受试者（n = 200）被分为AG组（n = 94）和非AG组（n = 106）。从上述七个候选基因中选择了30个标签SNP。分析了两组之间的SNP频率。AG组中 基因rs4683787位点的C/T或T/T基因型频率显著低于非AG组（P = 0.034，优势比 = 0.535）。基于多变量分析，rs4684787位点的C/C基因型和年龄与胃黏膜萎缩独立相关。这一发现有助于对需要及时进行内镜筛查或早期根除CagA的患者进行分层。
