• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

回顾性研究早孕期子宫出血:妊娠随访及与妊娠并发症出现的关系。

Retrospective Study of First Trimester Metrorrhagia: Pregnancy Follow-Up and Relationship with the Appearance of Gestational Complications.

机构信息

Medicine School, Malaga University, 29071 Málaga, Spain.

Obstetrics and Gynecology Service, Virgen de la Victoria University Hospital, 29010 Málaga, Spain.

出版信息

Medicina (Kaunas). 2023 Jul 27;59(8):1370. doi: 10.3390/medicina59081370.

DOI:10.3390/medicina59081370
PMID:37629660
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10456544/
Abstract

: The purpose of this study was to describe and evaluate the bleeding that occurs during the first weeks of gestation and its implications throughout pregnancy. Secondarily, we assessed the associated complications in order to identify potential risk factors that could be used to select women at higher risk of adverse outcomes that could benefit from an early diagnosis and improved monitoring. : We made a selection of all the women who consulted in the Emergency Department of the Hospital QuirónSalud in Malaga on 2015 presenting with first trimester metrorrhagia. We refer to first trimester metrorrhagia as that which occurs until week 12 + 6. Once these pregnant women were identified, we studied several variables not related to the gestation and some others associated with it and its natural course. : The average age of the patients assessed was 34.1. Associated gestational complications were metrorrhagia in the second trimester (6.3%), threatened preterm labor (7.4%), preeclampsia (2.5%), gestational diabetes (7.4%), late abortion (1.2%), and early postpartum hemorrhage (1.8%). We sought associations to assess possible risk factors, establishing an increased maternal age as an aggravating factor for the development of complications. We also studied gestational complications, finding a higher prevalence of them in older women, such as prematurity (33.11 vs. 34.48 years), gestational diabetes (33.11 vs. 36.06 years), and preeclampsia (33.25 vs. 35 years). : Maternal age is a risk factor for first-trimester spontaneous miscarriage and for the development of complications of pregnancy. It is crucial to perform a correct screening of different pathologies throughout the pregnancy to anticipate potential complications.

摘要

本研究旨在描述和评估妊娠早期出血及其在整个孕期的影响。其次,我们评估了相关并发症,以确定潜在的风险因素,这些因素可用于选择有更高不良结局风险的女性,以便进行早期诊断和改善监测。

我们选择了 2015 年在马拉加 QuirónSalud 医院急诊科就诊的所有因妊娠早期子宫出血而就诊的女性。我们将妊娠早期子宫出血定义为发生在第 12 周+6 天之前的出血。一旦确定了这些孕妇,我们就研究了与妊娠无关的几个变量和一些与妊娠及其自然病程相关的其他变量。

评估的患者平均年龄为 34.1 岁。与妊娠相关的并发症包括中期子宫出血(6.3%)、早产先兆(7.4%)、先兆子痫(2.5%)、妊娠期糖尿病(7.4%)、晚期流产(1.2%)和产后早期出血(1.8%)。我们寻求关联以评估可能的风险因素,发现母亲年龄增加是并发症发展的加重因素。我们还研究了妊娠并发症,发现老年女性的并发症发生率更高,如早产(33.11 岁 vs. 34.48 岁)、妊娠期糖尿病(33.11 岁 vs. 36.06 岁)和先兆子痫(33.25 岁 vs. 35 岁)。

母亲年龄是妊娠早期自发性流产和妊娠并发症发展的风险因素。在整个孕期正确筛查各种疾病以预测潜在并发症至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/655e8949aa60/medicina-59-01370-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/026fad43289f/medicina-59-01370-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/7be1573bba17/medicina-59-01370-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/dbff66060def/medicina-59-01370-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/1921787c1a3e/medicina-59-01370-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/26d23b59d10f/medicina-59-01370-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/0d02c0a09965/medicina-59-01370-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/ad812a25f3d4/medicina-59-01370-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/ca8f5a207da7/medicina-59-01370-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/cde7f704e6ce/medicina-59-01370-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/89a644e2dbf3/medicina-59-01370-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/59afd529c0a1/medicina-59-01370-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/4555b03a60e3/medicina-59-01370-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/2252ea37ace2/medicina-59-01370-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/1216868c6bcc/medicina-59-01370-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/0889725400d9/medicina-59-01370-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/4d35a27f4dae/medicina-59-01370-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/2df166643218/medicina-59-01370-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/27d7591d2ea6/medicina-59-01370-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/655e8949aa60/medicina-59-01370-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/026fad43289f/medicina-59-01370-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/7be1573bba17/medicina-59-01370-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/dbff66060def/medicina-59-01370-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/1921787c1a3e/medicina-59-01370-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/26d23b59d10f/medicina-59-01370-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/0d02c0a09965/medicina-59-01370-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/ad812a25f3d4/medicina-59-01370-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/ca8f5a207da7/medicina-59-01370-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/cde7f704e6ce/medicina-59-01370-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/89a644e2dbf3/medicina-59-01370-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/59afd529c0a1/medicina-59-01370-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/4555b03a60e3/medicina-59-01370-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/2252ea37ace2/medicina-59-01370-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/1216868c6bcc/medicina-59-01370-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/0889725400d9/medicina-59-01370-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/4d35a27f4dae/medicina-59-01370-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/2df166643218/medicina-59-01370-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/27d7591d2ea6/medicina-59-01370-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39f6/10456544/655e8949aa60/medicina-59-01370-g019.jpg

相似文献

1
Retrospective Study of First Trimester Metrorrhagia: Pregnancy Follow-Up and Relationship with the Appearance of Gestational Complications.回顾性研究早孕期子宫出血:妊娠随访及与妊娠并发症出现的关系。
Medicina (Kaunas). 2023 Jul 27;59(8):1370. doi: 10.3390/medicina59081370.
2
Pregnancy outcomes in nulliparous women with positive first-trimester preterm preeclampsia screening test: the Great Obstetrical Syndromes cohort study.初产妇中,早孕期子痫前期筛查阳性患者的妊娠结局:大型产科综合征队列研究。
Am J Obstet Gynecol. 2021 Feb;224(2):204.e1-204.e7. doi: 10.1016/j.ajog.2020.08.008. Epub 2020 Aug 7.
3
Metabolic and Hypertensive Complications of Pregnancy in Women with Nephrolithiasis.妊娠合并肾结石女性的代谢和高血压并发症。
Clin J Am Soc Nephrol. 2018 Apr 6;13(4):612-619. doi: 10.2215/CJN.12171017. Epub 2018 Feb 22.
4
Combination of first trimester serum afamin levels and three-dimensional placental bed vascularization as a possible screening method to detect women at-risk for adverse pregnancy complications like pre-eclampsia and gestational diabetes mellitus in low-risk pregnancies.将早孕期血清 afamin 水平与三维胎盘床血管化相结合,作为一种可能的筛查方法,以检测低危妊娠中发生子痫前期和妊娠期糖尿病等不良妊娠并发症风险的孕妇。
Placenta. 2018 Feb;62:9-15. doi: 10.1016/j.placenta.2017.12.014. Epub 2017 Dec 15.
5
Vanishing twin syndrome is associated with first-trimester intrauterine hematoma in twin pregnancies after fertilization.消失的双胞胎综合征与受精后第一个三个月内的双胞胎妊娠子宫内血肿有关。
Front Endocrinol (Lausanne). 2023 Jan 13;13:1062303. doi: 10.3389/fendo.2022.1062303. eCollection 2022.
6
First trimester fasting plasma glucose screen in advanced maternal age women: a cost-effectiveness analysis.高龄孕妇早孕期空腹血糖筛查:成本效益分析。
J Matern Fetal Neonatal Med. 2022 Nov;35(21):4123-4129. doi: 10.1080/14767058.2020.1847073. Epub 2020 Nov 12.
7
Modified multiple marker aneuploidy screening as a primary screening test for preeclampsia.采用改良的多重标志物三体非整倍体筛查作为子痫前期的初筛检测方法。
BMC Pregnancy Childbirth. 2022 Mar 8;22(1):190. doi: 10.1186/s12884-022-04514-4.
8
Maternal age and adverse pregnancy outcome: a cohort study.母亲年龄与不良妊娠结局:一项队列研究。
Ultrasound Obstet Gynecol. 2013 Dec;42(6):634-43. doi: 10.1002/uog.12494.
9
First trimester serum afamin concentrations are associated with the development of pre-eclampsia and gestational diabetes mellitus in pregnant women.早孕期血清 afamin 浓度与孕妇子痫前期和妊娠期糖尿病的发生有关。
Clin Chim Acta. 2018 Jan;476:160-166. doi: 10.1016/j.cca.2017.11.031. Epub 2017 Nov 27.
10
The change in concentrations of angiogenic and anti-angiogenic factors in maternal plasma between the first and second trimesters in risk assessment for the subsequent development of preeclampsia and small-for-gestational age.孕早期与孕中期母血中血管生成因子和抗血管生成因子浓度变化在子痫前期和小于胎龄儿后续发生风险评估中的作用
J Matern Fetal Neonatal Med. 2008 May;21(5):279-87. doi: 10.1080/14767050802034545.

本文引用的文献

1
Abortion Surveillance - United States, 2020.《2020 年美国堕胎监测》
MMWR Surveill Summ. 2022 Nov 25;71(10):1-27. doi: 10.15585/mmwr.ss7110a1.
2
Pre-viable preterm premature rupture of membranes under 20 weeks of pregnancy: A retrospective cohort analysis for potential outcome predictors.20 周妊娠前可行早产胎膜早破:潜在结局预测因素的回顾性队列分析。
Eur J Obstet Gynecol Reprod Biol. 2022 Nov;278:177-182. doi: 10.1016/j.ejogrb.2022.09.025. Epub 2022 Sep 30.
3
Mid-trimester uterine electromyography in patients with a short cervix.
中孕期子宫肌电图在短宫颈患者中的应用。
Am J Obstet Gynecol. 2022 Jul;227(1):83.e1-83.e17. doi: 10.1016/j.ajog.2022.03.046. Epub 2022 Mar 26.
4
Predictors for insulin use in gestational diabetes mellitus.妊娠期糖尿病胰岛素使用的预测因素。
Eur J Obstet Gynecol Reprod Biol. 2022 May;272:177-181. doi: 10.1016/j.ejogrb.2022.03.025. Epub 2022 Mar 14.
5
Trends in maternal age and the relationship between advanced age and adverse pregnancy outcomes: a population-based register study in Wuhan, China, 2010-2017.孕产妇年龄趋势以及高龄与不良妊娠结局之间的关系:一项基于人群的中国武汉2010 - 2017年登记研究
Public Health. 2022 May;206:8-14. doi: 10.1016/j.puhe.2022.02.015. Epub 2022 Mar 17.
6
Individualized treatment of preterm premature rupture of membranes to prolong the latency period, reduce the rate of preterm birth, and improve neonatal outcomes.对早产胎膜早破进行个体化治疗以延长潜伏期、降低早产率并改善新生儿结局。
Am J Obstet Gynecol. 2022 Aug;227(2):296.e1-296.e18. doi: 10.1016/j.ajog.2022.02.037. Epub 2022 Mar 5.
7
Impact of maternal age on perinatal outcomes in twin pregnancies: a systematic review and meta-analysis.母亲年龄对双胞胎妊娠围产结局的影响:系统评价和荟萃分析。
Eur Rev Med Pharmacol Sci. 2022 Jan;26(1):99-109. doi: 10.26355/eurrev_202201_27753.
8
A population-based study of the relationship between advanced maternal age and premature/early-term birth in Brazil.基于人群的研究:巴西高龄产妇与早产/早期产之间的关系。
Int J Gynaecol Obstet. 2022 Oct;159(1):173-181. doi: 10.1002/ijgo.14057. Epub 2021 Dec 20.
9
Pregnancy outcomes in very advanced maternal age women.高龄孕产妇的妊娠结局
Am J Obstet Gynecol MFM. 2022 Jan;4(1):100491. doi: 10.1016/j.ajogmf.2021.100491. Epub 2021 Sep 17.
10
Absolute Risk of Adverse Obstetric Outcomes Among Twin Pregnancies After In Vitro Fertilization by Maternal Age.体外受精后母亲年龄对双胎妊娠不良产科结局的绝对风险。
JAMA Netw Open. 2021 Sep 1;4(9):e2123634. doi: 10.1001/jamanetworkopen.2021.23634.