Radoi Cristiana Luiza, Zlatian Ovidiu, Balasoiu Maria, Giubelan Lucian, Stoian Andreea Cristina, Dragonu Livia, Neacsu Alexandru, Iliescu Dominic Gabriel
Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Medical Laboratory, County Clinical Emergency Hospital of Craiova, 200349 Craiova, Romania.
Microorganisms. 2023 Aug 20;11(8):2120. doi: 10.3390/microorganisms11082120.
Maternal-fetal infectious pathology-notably the TORCH panel (, rubella, Cytomegalovirus, and herpes simplex viruses)-critically impacts maternal and neonatal health. This review collates data on the seroprevalence of IgG and IgM antibodies against TORCH agents in Romanian women, aiming to discern regional and population differences and identify risk factors. Twenty studies were included in the review, revealing variable seroprevalence rates across the country. Regions such as Moldavia and Banat showed higher anti- IgG seroprevalence rates than Bihor, with notable declines in Banat. Rural, older, and multiparous women showed elevated IgG rates. Anti-rubella vaccine introduction significantly reduced the prevalence of anti-rubella IgG antibodies, but recent vaccination coverage decreases raise concerns. CMV and HSV seroprevalence varied geographically, with rural areas generally showing higher CMV rates and HSV influenced by factors like education level and number of sexual partners. Concurrent seroprevalence of multiple TORCH components in some cases underscores potential common risk factors. This study highlights the importance of continuous monitoring and preventive measures such as vaccinations and awareness campaigns to mitigate the health impact on the pregnant population.
母胎感染性病理学——尤其是TORCH组（弓形虫、风疹、巨细胞病毒和单纯疱疹病毒）——对孕产妇和新生儿健康有着至关重要的影响。本综述整理了罗马尼亚女性中针对TORCH病原体的IgG和IgM抗体血清阳性率的数据，旨在识别地区和人群差异并确定风险因素。该综述纳入了20项研究，揭示了全国范围内不同的血清阳性率。摩尔多瓦和巴纳特等地区的抗风疹IgG血清阳性率高于比霍尔，巴纳特地区的该阳性率有显著下降。农村、年龄较大和经产妇的IgG阳性率较高。风疹疫苗的引入显著降低了抗风疹IgG抗体的患病率，但近期疫苗接种覆盖率的下降令人担忧。巨细胞病毒和单纯疱疹病毒的血清阳性率在地理上存在差异，农村地区的巨细胞病毒血清阳性率通常较高，而单纯疱疹病毒受教育水平和性伴侣数量等因素影响。某些情况下多种TORCH成分的同时血清阳性率凸显了潜在的共同风险因素。本研究强调了持续监测以及诸如疫苗接种和提高认识运动等预防措施对于减轻对孕妇群体健康影响的重要性。
