克罗地亚育龄妇女中TORCH感染的血清阳性率。

Seroprevalence of TORCH infections in women of childbearing age in Croatia.

作者信息

Vilibic-Cavlek Tatjana, Ljubin-Sternak Suncanica, Ban Mirela, Kolaric Branko, Sviben Mario, Mlinaric-Galinovic Gordana

机构信息

Virology Department, Croatian National Institute of Public Health, Zagreb, Croatia.

出版信息

J Matern Fetal Neonatal Med. 2011 Feb;24(2):280-3. doi: 10.3109/14767058.2010.485233. Epub 2010 May 17.

DOI:10.3109/14767058.2010.485233

PMID:20476874

Abstract

During 2005-2009, a seroepidemiological study was carried out in Croatia to define the population susceptible to common TORCH agents among pregnant and non-pregnant women of childbearing age. The IgG seroprevalence was 29.1% forT. gondii, 94.6% for rubella, 75.3% for cytomegalovirus (CMV), 78.7% for herpes simplex virus type 1 (HSV-1), and 6.8% for HSV-2. Acute toxoplasmosis and CMV infection (positive IgM antibodies with low IgG avidity) were documented in 0.25% and 0.09% women, respectively. IgM prevalence was 1.2% for both HSV-1 and HSV-2. None of the participants showed acute rubella infection. Seropositivity to T. gondii and HSV-2 varied significantly between age groups (p = 0.001 and p = 0.036, respectively). Women residing in rural regions showed a significantly higher seroprevalence rate for T. gondii, CMV, and HSV-1 than urban women (T. gondii: 44.0% vs. 25.4%, p < 0.001; CMV: 85.0% vs. 73.1%, p = 0.018; HSV-1: 86.0% vs. 76.4%, p = 0.041).

摘要

2005年至2009年期间，在克罗地亚开展了一项血清流行病学研究，以确定育龄孕妇和非孕妇中对常见TORCH病原体易感的人群。弓形虫的IgG血清阳性率为29.1%，风疹为94.6%，巨细胞病毒（CMV）为75.3%，1型单纯疱疹病毒（HSV-1）为78.7%，2型单纯疱疹病毒（HSV-2）为6.8%。分别有0.25%和0.09%的女性被记录为急性弓形虫病和CMV感染（IgM抗体阳性且IgG亲和力低）。HSV-1和HSV-2的IgM阳性率均为1.2%。没有参与者表现出急性风疹感染。弓形虫和HSV-2的血清阳性率在不同年龄组之间有显著差异（分别为p = 0.001和p = 0.036）。居住在农村地区的女性弓形虫、CMV和HSV-1的血清阳性率显著高于城市女性（弓形虫：44.0%对25.4%，p < 0.001；CMV：85.0%对73.1%，p = 0.018；HSV-1：86.0%对76.4%，p = 0.041）。