Gaona-López Carlos, Martínez-Vázquez Ana Verónica, Villalobos-Rocha Juan Carlos, Juárez-Rendón Karina Janett, Rivera Gildardo
Laboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Mexico.
Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, Mexico.
Pharmaceuticals (Basel). 2023 Aug 16;16(8):1168. doi: 10.3390/ph16081168.
() is the main causative agent of diarrhea worldwide, affecting children and adults alike; in the former, it can be lethal, and in the latter a strong cause of morbidity. Despite being considered a predominant disease in low-income and developing countries, current migratory flows have caused an increase in giardiasis cases in high-income countries. Currently, there is a wide variety of chemotherapeutic treatments to combat this parasitosis, most of which have potentially serious side effects, such as genotoxic, carcinogenic, and teratogenic. The necessity to create novel treatments and discover new therapeutic targets to fight against this illness is evident. The current review centers around the controversial nucleolus of , providing a historical perspective that traces its apparent absence to the present evidence supporting its existence as a subnuclear compartment in this organism. Additionally, possible examples of ncRNAs and proteins ubiquitous to the nucleolus that can be used as targets of different therapeutic strategies are discussed. Finally, some examples of drugs under research that could be effective against are described.
（）是全球腹泻的主要致病原，对儿童和成人都会造成影响；在儿童中，它可能是致命的，而在成人中则是发病的重要原因。尽管被认为是低收入和发展中国家的主要疾病，但当前的移民潮导致高收入国家的贾第虫病病例有所增加。目前，有各种各样的化疗方法来对抗这种寄生虫病，其中大多数都有潜在的严重副作用，如基因毒性、致癌性和致畸性。显然有必要研发新的治疗方法并发现新的治疗靶点来对抗这种疾病。当前的综述围绕着（）存在争议的核仁展开，提供了一个历史视角，追溯了其看似不存在到目前支持其作为该生物体亚核区室存在的证据。此外，还讨论了核仁中普遍存在的非编码RNA和蛋白质作为不同治疗策略靶点的可能例子。最后，描述了一些正在研究的可能有效对抗（）的药物例子。
