Guy J, Schatz N J
Ophthalmology. 1986 Aug;93(8):1083-8. doi: 10.1016/s0161-6420(86)33617-0.
Four patients with radiation-induced optic neuropathies were treated with hyperbaric oxygen. They had received radiation therapy for treatment of pituitary tumors, reticulum cell sarcoma, and meningioma. Two presented with amaurosis fugax before the onset of unilateral visual loss and began hyperbaria within 72 hours after development of unilateral optic neuropathy. Both had return of visual function to baseline levels. The others initiated treatment two to six weeks after visual loss occurred in the second eye and had no significant improvement of vision. Treatment consisted of daily administration of 100% oxygen under 2.8 atmospheres of pressure for 14-28 days. There were no medical complications of hyperbaria. While hyperbaric oxygen is effective in the treatment of radiation-induced optic neuropathy, it must be instituted within several days of deterioration in vision for restoration of baseline function.
四名放射性视神经病变患者接受了高压氧治疗。他们曾因垂体瘤、网状细胞肉瘤和脑膜瘤接受放射治疗。两名患者在单侧视力丧失发作前出现一过性黑矇，并在单侧视神经病变出现后72小时内开始高压氧治疗。两人的视觉功能均恢复至基线水平。另外两人在第二眼视力丧失发生两至六周后开始治疗，视力无明显改善。治疗方法为在2.8个大气压下每日给予100%氧气，持续14至28天。高压氧治疗无医学并发症。虽然高压氧对放射性视神经病变有效，但必须在视力恶化数天内开始治疗，才能恢复基线功能。
