Department of Ophthalmology, Cincinnati Eye Institute, University of Cincinnati, Cincinnati, OH, USA.
J Neuroophthalmol. 2012 Jun;32(2):128-31. doi: 10.1097/WNO.0b013e3182464c88.
Radiation optic neuropathy (RON) is characterized by the rapid onset of painless irreversible vision loss in one or both eyes. We report 4 consecutive patients who presented with unilateral or asymmetric bilateral RON. All had bilateral optic nerve enhancement on MRI and were treated with hyperbaric oxygen (HBO) and oral corticosteroids. In the less affected eye, 2 of the 4 patients had preservation of vision, while in the other 2 patients, vision declined. No patient showed improvement in the more symptomatic eye, and in 2 patients, there was a significant decline in visual acuity. Our findings suggest that prompt treatment with HBO and oral corticosteroids may result in visual preservation in the less affected eye despite the presence of optic nerve enhancement on MRI.
放射性视神经病变（RON）的特征是单侧或双侧不对称的双眼无痛性、不可逆的视力丧失迅速发生。我们报告了 4 例连续患者，他们表现为单侧或双侧 RON。所有患者的 MRI 均显示双侧视神经增强，并接受高压氧（HBO）和口服皮质类固醇治疗。在病情较轻的眼睛中，4 例中的 2 例视力得以保留，而在另外 2 例中，视力下降。在症状更严重的眼睛中，没有患者的视力得到改善，在 2 例患者中，视力明显下降。我们的研究结果表明，尽管 MRI 显示视神经增强，但及时进行 HBO 和口服皮质类固醇治疗可能会导致病情较轻的眼睛视力得以保留。
