Scelsi R, Poggi P, Padovani R, Lotta S, Cairoli S, Saitta A
Paraplegia. 1986 Aug;24(4):250-9. doi: 10.1038/sc.1986.35.
Pourpre's dorsal T-shaped myelotomy was performed on three paraplegic patients in which medical and electro-physiological procedures proved to be ineffective concerning muscle spasms. The myelotomy led to the elimination of spasms and of muscle hypertonicity in the lower limbs. Biopsies of the rectus femoris muscles were performed bilaterally one year before and two months following myelotomy. The first biopsy revealed fascicular atrophy, with type I fibre preferential atrophy, which is usually found in paraplegic patients. After myelotomy some histological differences were seen: reduction of type II fibre diameter and the presence of target-targetoid fibres and of atrophic dark fibres. There was a difference of fibre pattern type in hypertonic spastic muscles compared to that seen in spasm relieved by myelotomy. The morphological changes seen after myelotomy are interpreted as denervation changes because of the surgical lesion by the myelotomy on the anterior horn cells.
对三名截瘫患者实施了普尔普雷（Pourpre）背侧 T 形脊髓切开术，在这些患者中，药物和电生理治疗方法被证明对肌肉痉挛无效。脊髓切开术消除了下肢的痉挛和肌肉张力亢进。在脊髓切开术前一年和术后两个月对双侧股直肌进行活检。首次活检显示束状萎缩，以 I 型纤维优先萎缩为主，这在截瘫患者中较为常见。脊髓切开术后可见一些组织学差异：II 型纤维直径减小，出现靶形-类靶形纤维和萎缩性暗纤维。与脊髓切开术缓解痉挛的肌肉相比，高张力痉挛肌肉的纤维模式类型存在差异。脊髓切开术后出现的形态学变化被解释为由于脊髓切开术对前角细胞造成的手术损伤导致的去神经变化。
