van Baarle Lies, Stakenborg Michelle, Matteoli Gianluca
Department of Chronic Diseases and Metabolism (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Herestraat 49, O&N1 box 701, 3000 Leuven, Belgium.
Department of Chronic Diseases and Metabolism (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Herestraat 49, O&N1 box 701, 3000 Leuven, Belgium.
Semin Immunol. 2023 Nov;70:101819. doi: 10.1016/j.smim.2023.101819. Epub 2023 Aug 25.
The enteric nervous system is an autonomous neuronal circuit that regulates many processes far beyond the peristalsis in the gastro-intestinal tract. This circuit, consisting of enteric neurons and enteric glial cells, can engage in many intercellular interactions shaping the homeostatic microenvironment in the gut. Perhaps the most well documented interactions taking place, are the intestinal neuro-immune interactions which are essential for the fine-tuning of oral tolerance. In the context of intestinal disease, compelling evidence demonstrates both protective and detrimental roles for this bidirectional neuro-immune signaling. This review discusses the different immune cell types that are recognized to engage in neuronal crosstalk during intestinal health and disease. Highlighting the molecular pathways involved in the neuro-immune interactions might inspire novel strategies to target intestinal disease.
肠神经系统是一个自主神经元回路，其调节的许多过程远远超出胃肠道的蠕动。这个由肠神经元和肠胶质细胞组成的回路，可以参与许多细胞间相互作用，塑造肠道内的稳态微环境。也许记录最详尽的相互作用是肠道神经免疫相互作用，这对口服耐受性的微调至关重要。在肠道疾病的背景下，有力证据表明这种双向神经免疫信号既有保护作用，也有有害作用。本综述讨论了在肠道健康和疾病期间被认为参与神经元串扰的不同免疫细胞类型。突出神经免疫相互作用中涉及的分子途径可能会激发针对肠道疾病的新策略。
