Nielsen Martin K, Kaplan Ray M, Abbas Ghazanfar, Jabbar Abdul
M.H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY, USA.
School of Veterinary Medicine, St George's University, Grenada, West Indies.
Trends Parasitol. 2023 Nov;39(11):945-953. doi: 10.1016/j.pt.2023.08.002. Epub 2023 Aug 24.
Long-term intensive use of anthelmintics for parasite control of livestock, companion animals, and humans has resulted in widespread anthelmintic resistance, a problem of great socioeconomic significance. But anthelmintic therapy may also select for other biological traits, which could have implications for anthelmintic performance. Here, we highlight recent examples of changing parasite dynamics following anthelmintic administration, which do not fit the definition of anthelmintic resistance. We also consider other possible examples in which anthelmintic resistance has clearly established, but where coselection for other biological traits may have also occurred. We offer suggestions for collecting more information and gaining a better understanding of these phenomena. Finally, we propose research questions that require further investigation and make suggestions to help address these knowledge gaps.
长期大量使用驱虫药来控制家畜、伴侣动物和人类体内的寄生虫，已导致驱虫药广泛耐药，这是一个具有重大社会经济意义的问题。但驱虫治疗也可能会选择其他生物学特性，这可能会对驱虫效果产生影响。在此，我们重点介绍了驱虫药给药后寄生虫动态变化的近期实例，这些实例不符合驱虫药耐药性的定义。我们还考虑了其他一些可能的实例，其中驱虫药耐药性已明确存在，但也可能同时发生了对其他生物学特性的共选择。我们提供了收集更多信息并更好地理解这些现象的建议。最后，我们提出了需要进一步研究的问题，并给出了有助于填补这些知识空白的建议。
