Ritter R C, Kalivas P, Bernier S
Peptides. 1986 Jul-Aug;7(4):587-90. doi: 10.1016/0196-9781(86)90031-8.
Cholecystokinin (CCK), a peptide found in both gastrointestinal endocrine cells and neurons, suppresses food intake and reduces locomotor behavior when injected systemically. Both the locomotor and ingestive effects of CCK are abolished by subdiaphragmatic vagotomy. Pretreatment of adult rats with capsaicin attenuates the reduced locomotor activity and reduced food intake which normally occurs following injection of exogenous cholecystokinin. Since capsaicin damages or destroys small-diameter, unmyelinated, sensory neurons, including vagal sensory fibers, these data support the interpretation that both CCK-induced suppression of food intake and CCK-induced reduction of locomotion are mediated by fine, unmyelinated sensory neurons.
胆囊收缩素（CCK）是一种存在于胃肠道内分泌细胞和神经元中的肽，全身注射时可抑制食物摄入并减少运动行为。膈下迷走神经切断术可消除CCK对运动和摄食的影响。用辣椒素预处理成年大鼠可减弱注射外源性胆囊收缩素后通常出现的运动活动减少和食物摄入减少的情况。由于辣椒素会损伤或破坏小直径、无髓鞘的感觉神经元，包括迷走神经感觉纤维，这些数据支持这样的解释，即CCK诱导的食物摄入抑制和CCK诱导的运动减少均由细的、无髓鞘的感觉神经元介导。
