Ritter R C, Ladenheim E E
Am J Physiol. 1985 Apr;248(4 Pt 2):R501-4. doi: 10.1152/ajpregu.1985.248.4.R501.
Capsaicin, the pungent principal in red pepper, has been shown to damage small-diameter peptide-containing sensory neurons. Suppression of feeding by cholecystokinin octapeptide (CCK OP) was attenuated after systemic pretreatment with capsaicin. Capsaicin pretreatment did not attenuate suppression of food intake by intragastric preloads. Pretreatment of rats with microgram quantities of capsaicin injected into the fourth ventricle, near the sites of vagal afferent termination, also attenuated CCK OP-induced suppression of food intake. These results suggest that the satiety-inducing effects of CCK OP are mediated, at least in part, by capsaicin-sensitive afferent neurons.
辣椒素是红辣椒中的辛辣成分，已被证明会损伤含肽的小直径感觉神经元。用辣椒素进行全身预处理后，胆囊收缩素八肽（CCK-OP）对摄食的抑制作用减弱。辣椒素预处理并未减弱胃内预负荷对食物摄入的抑制作用。向第四脑室（迷走神经传入神经末梢附近）注射微克量的辣椒素对大鼠进行预处理，也减弱了CCK-OP诱导的食物摄入抑制作用。这些结果表明，CCK-OP的饱腹感诱导作用至少部分是由辣椒素敏感的传入神经元介导的。
