Deng Junxia, Wang Zhen, Xing Jinfeng
School of Chemical Engineering and Technology, Tianjin University, No. 135 Yaguan Road, Haihe Education Park, Jinnan District, Tianjin 300350, China.
School of Chemical Engineering and Technology, Tianjin University, No. 135 Yaguan Road, Haihe Education Park, Jinnan District, Tianjin 300350, China.
J Mech Behav Biomed Mater. 2023 Oct;146:106079. doi: 10.1016/j.jmbbm.2023.106079. Epub 2023 Aug 22.
Hemostatic powders can be used for deep wounds and wounds with irregular shapes that are frequently inaccessible to traditional hemostatic dressings like hemostatic gauze, sponges, and foams. In this study, sulfobetaine methacrylate (SBMA) and quaternized carboxymethyl chitosan (QCCS) were combined to create an antibacterial hemostatic hydrogel through photopolymerization under green LED irradiation, which was then changed into PSBMA/QCCS powder. PSBMA/QCCS powder could quickly form hydrogel with strong wet adhesion. The internal structure, water absorption capacity, and adhesion properties of the powder were evaluated. The coagulation ability, antimicrobial properties, and biocompatibility of the powder were also characterized. The PSBMA/QCCS powder could aggregate blood cells and platelets to enhance hemostasis. Meanwhile, PSBMA/QCCS powder also showed effective antibacterial ability against both gram-positive bacteria (Staphylococcus aureus) and gram-negative bacteria (Escherichia coli). In summary, PSBMA/QCCS powder is a promising hemostatic agent with the characteristics of quick hemostasis, tough wet adhesion, satisfactory biocompatibility, considerable antibacterial effect, and adaptability to any irregularly shaped wounds.
止血粉可用于深部伤口以及形状不规则的伤口，这些伤口通常是传统止血敷料（如止血纱布、海绵和泡沫）难以触及的。在本研究中，甲基丙烯酰基磺酸甜菜碱（SBMA）和季铵化羧甲基壳聚糖（QCCS）通过在绿色LED照射下光聚合反应结合，制成一种抗菌止血水凝胶，然后将其转变为PSBMA/QCCS粉末。PSBMA/QCCS粉末能够快速形成具有强湿粘性的水凝胶。对该粉末的内部结构、吸水能力和粘附性能进行了评估。还对该粉末的凝血能力、抗菌性能和生物相容性进行了表征。PSBMA/QCCS粉末能够聚集血细胞和血小板以增强止血效果。同时，PSBMA/QCCS粉末对革兰氏阳性菌（金黄色葡萄球菌）和革兰氏阴性菌（大肠杆菌）均显示出有效的抗菌能力。总之，PSBMA/QCCS粉末是一种有前景的止血剂，具有快速止血、强湿粘性、良好生物相容性、显著抗菌效果以及适用于任何形状不规则伤口的特点。
