Li Jia, Li Shu, Zhong Aozhen, Xing Jun, Li Ling, Wang Cai, Zheng Min
School of Biomedical Engineering and Imaging, Xianning Medical College, Hubei University of Science and Technology, Xianning 437100, China.
Polymers (Basel). 2024 Dec 18;16(24):3516. doi: 10.3390/polym16243516.
Powder-based hemostatic materials have offered unprecedented opportunities for the effective sealing and repair of irregularly shaped wounds and high-pressure, noncompressible arterial bleeding wounds caused by surgeries, traffic accidents, and wartime injuries. However, inadequate adhesion to bleeding wounds and poor hemostasis in biological tissues remains challenging. Herein, we report a self-gelling hemostatic powder based on polyacrylic acid/polyethyleneimine/polyethylene glycol (named PPG) for rapid hemostasis and effective antibacterial ability. When deposited on bleeding wounds, PPG powder can absorb interfacial liquid and rapidly swell into a physically cross-linked hydrogel in situ within 2 s to form a pressure-resistant physical barrier. Furthermore, the in vivo and in vitro results indicate that, as an effective sealant, the PPG powder possesses ease of use, excellent hemocompatibility, strong antibacterial abilities, and superior blood clotting abilities. The effective hemostatic sealing capability of the PPG powder is demonstrated in a variety of injury models in rats and rabbits. All of these factors show that, with its superior wound treatment abilities, PPG powder is a profound biomaterial for surgical applications.
基于粉末的止血材料为有效密封和修复由手术、交通事故和战时创伤引起的不规则形状伤口以及高压、不可压缩的动脉出血伤口提供了前所未有的机会。然而，对出血伤口的粘附不足以及在生物组织中的止血效果不佳仍然具有挑战性。在此，我们报道了一种基于聚丙烯酸/聚乙烯亚胺/聚乙二醇（命名为PPG）的自凝胶止血粉末，具有快速止血和有效的抗菌能力。当沉积在出血伤口上时，PPG粉末可以吸收界面液体并在2秒内迅速原位溶胀成物理交联水凝胶，形成耐压物理屏障。此外，体内和体外结果表明，作为一种有效的密封剂，PPG粉末具有使用方便、优异的血液相容性、强大的抗菌能力和卓越的凝血能力。PPG粉末的有效止血密封能力在大鼠和兔子的多种损伤模型中得到了证明。所有这些因素表明，凭借其卓越的伤口治疗能力，PPG粉末是一种用于外科应用的有深远意义的生物材料。
