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Enhanced binding of 3H-arginine8-vasopressin in the Brattleboro rat.

作者信息

Shewey L M, Dorsa D M

出版信息

Peptides. 1986 Jul-Aug;7(4):701-4. doi: 10.1016/0196-9781(86)90047-1.

DOI:10.1016/0196-9781(86)90047-1
PMID:3763443
Abstract

Specific binding sites for 3[H]-arginine8-vasopressin (AVP) were characterized using membrane preparations of liver, renal medulla and brain (septal) tissue of heterozygous (HE) and homozygous (HO) Brattleboro (BB) rats. Measurement of binding sites indicated that significantly greater numbers of AVP receptors are present in the liver and septum of HO-BB rats. Similar numbers of AVP receptors were present in renal medullary tissue from HO-BB and HE-BB rats. Higher equilibrium dissociation constants were measured in the HO-BB septal tissue indicating a lower affinity of the brain receptor for 3[H]-AVP than in heterozygotes. No significant differences in AVP receptor affinity were noted in liver or kidney tissue. It is concluded that "up-regulation" of AVP receptor number and, in the brain, alterations in AVP receptor affinity may occur in the absence of endogenous AVP.

摘要

相似文献

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Enhanced binding of 3H-arginine8-vasopressin in the Brattleboro rat.
Peptides. 1986 Jul-Aug;7(4):701-4. doi: 10.1016/0196-9781(86)90047-1.
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Characterization and localization of 3H-arginine8-vasopressin binding to rat kidney and brain tissue.
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Characterization of a specific, high affinity [3H]arginine8 vasopressin-binding site on liver microsomes from different strains of rat and the role of magnesium.不同品系大鼠肝微粒体上特异性、高亲和力[³H]精氨酸⁸血管加压素结合位点的特性及镁的作用
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Pituitary binding of vasopressin is altered by experimental manipulations of the hypothalamo-pituitary-adrenocortical axis in normal as well as homozygous (di/di) Brattleboro rats.在正常以及纯合子（di/di）布拉特洛维大鼠中，通过对下丘脑-垂体-肾上腺皮质轴进行实验性操作，血管加压素的垂体结合情况会发生改变。
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Neuroendocrinology. 1986;43(5):618-24. doi: 10.1159/000124590.

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