Center for Environmental Remediation, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China; Department of Chemical and Environmental Engineering, University of Nottingham Ningbo China, 199 Taikang E Rd, Ningbo 315100, China.
School of Public Health, University of Memphis, Memphis, TN, 38152, USA.
Environ Pollut. 2023 Nov 1;336:122437. doi: 10.1016/j.envpol.2023.122437. Epub 2023 Aug 25.
Particulate matter (PM) inhaled into human lungs causes oxidative stress and adverse health effects through antioxidant depletion (oxidative potential, OP). However, there is limited knowledge regarding the association between the lung-deposited dose (LDD) of PM and OP in extrathoracic (ET), tracheobronchial (TB), and pulmonary (P) regions of human lungs. Dithiothreitol (DTT) and ascorbic acid (AA) assays were employed to measure the OP of PM size fractions to investigate OP distribution in human lungs and identify the chemical drivers. Quasi-ultrafine particles (quasi-UFP, ≤0.49 μm) exhibited high OP deposition in the TB and P regions, while coarse particles (CP, ≥3.0 μm) dominated in the ET region. A plot of extrinsic (per air volume) and intrinsic (per PM mass) OP versus LDD revealed that the OP for fine and coarse particles was greatest in the ET region, whereas the OP of quasi-UFP was greatest in alveoli. The study also demonstrated that extrinsic OP and PM doses are not strongly related. The decline in OP with increasing PM dose reveals the need for further investigation of the antagonistic effects of the chemical compositions. Overall, the results presented herein help address the gap in knowledge regarding the association between the OP and LDD of ambient particles in specific regions of human lungs.
吸入人体肺部的颗粒物（PM）通过抗氧化剂耗竭（氧化势能，OP）引起氧化应激和不良健康影响。然而，关于 PM 肺部沉积剂量（LDD）与人体肺部的胸外（ET）、气管支气管（TB）和肺（P）区域 OP 之间的关联，我们的了解有限。采用二硫苏糖醇（DTT）和抗坏血酸（AA）测定法来测量 PM 粒度分数的 OP，以研究 PM 在人体肺部的分布情况并确定化学驱动因素。二硫苏糖醇（DTT）和抗坏血酸（AA）测定法来测量 PM 粒度分数的 OP，以研究 PM 在人体肺部的分布情况并确定化学驱动因素。准超细微粒（quasi-UFP，≤0.49μm）在 TB 和 P 区域表现出高 OP 沉积，而粗颗粒（CP，≥3.0μm）在 ET 区域占主导地位。外在（每空气体积）和内在（每 PM 质量）OP 与 LDD 的关系图表明，细颗粒和粗颗粒的 OP 在 ET 区域最大，而准 UFP 的 OP 在肺泡中最大。该研究还表明，外在 OP 和 PM 剂量之间没有很强的相关性。随着 PM 剂量的增加，OP 下降表明需要进一步研究化学成分的拮抗作用。总的来说，本文的研究结果有助于填补关于特定人体肺部区域环境颗粒物 OP 和 LDD 之间关联的知识空白。
