Wei Chengjie, Hou Xiaomin, Jiang Xuelu, Gao Ming, Gao Yan, Bi Lin, Nie Jisheng, Zhao Liangyuan, Shi Yiwei, Qin Xiaojiang
Academy of Medical Science, Shanxi Medical University, Taiyuan, Shanxi, China.
Department of Pharmacology, Shanxi Medical University, Taiyuan, Shanxi, China.
J Cell Mol Med. 2025 Jun;29(11):e70534. doi: 10.1111/jcmm.70534.
Grey hair, a common ageing-associated phenomenon in humans, is mainly attributed to the damage of melanocytes and the absence of melanin. Grey hair has long been treated with traditional medicine, and new research has shown that various plant-derived monomers can increase tyrosinase activity and melanogenesis, indicating that they may have therapeutic value in curing grey hair. In this study, we outlined the role of melanin and pigmentation during hair growth and collected various medicinal plant monomers with the potential value of grey hair reversal. Many active ingredients from medicinal plants, such as fraxinol, tribuloside, morin and naringenin, can upregulate melanogenesis and tyrosinase activity through different signalling pathways. Some of them can promote melanosome quantity, maturation and transportation as well. Monomers isolated from medicinal plants may act as stimulators of melanogenesis. Many plant-derived monomers perform as activators that upregulate melanin synthesis and tyrosinase activity through different signalling pathways. They are of great research value for the treatment of hair greying. Moreover, to further improve experimental effect, safety and reliability, a systematic and comprehensive evaluation system needs to be established in the future before studying their clinical efficacy.
白发是人类常见的与衰老相关的现象，主要归因于黑素细胞的损伤和黑色素的缺失。长期以来，传统医学一直在治疗白发，新的研究表明，各种植物来源的单体可以增加酪氨酸酶活性和黑色素生成，这表明它们在治疗白发方面可能具有治疗价值。在本研究中，我们概述了黑色素和色素沉着在头发生长过程中的作用，并收集了具有逆转白发潜在价值的各种药用植物单体。许多药用植物的活性成分，如秦皮素、刺蒺藜苷、桑色素和柚皮素，可以通过不同的信号通路上调黑色素生成和酪氨酸酶活性。其中一些还可以促进黑素小体的数量、成熟和运输。从药用植物中分离出的单体可能作为黑色素生成的刺激剂。许多植物来源的单体作为激活剂，通过不同的信号通路上调黑色素合成和酪氨酸酶活性。它们在治疗白发方面具有很大的研究价值。此外，为了进一步提高实验效果、安全性和可靠性，未来在研究其临床疗效之前，需要建立一个系统、全面的评价体系。
