Gaffney E F, Vellios F, Hargreaves H K
Pediatr Pathol. 1986;5(2):207-16. doi: 10.3109/15513818609041202.
Two cases of lipoblastomatosis were examined by electron microscopy. In each there was a spectrum of adipose cell differentiation from mature adipocytes to undifferentiated mesenchymal cells. The cells had various shapes and were loosely related to one another and to small blood vessels in a stroma containing sparse collagen and proteoglycan granules. Adipocytes and lipoblasts had a discrete basal lamina but this was absent in immature mesenchymal cells, which had prominent intermediate (10-nm) microfilaments and few or no lipid droplets. Neither case had foci resembling brown adipose tissue or hibernoma (large polygonal cells closely apposed to one another and to capillaries with densely packed pleomorphic mitochondria and focal undulating plasmalemmal invaginations). Both the ultrastructure of lipoblastomatosis and its characteristic loose lobular arrangement by light microscopy closely resemble human fetal "white" adipose tissue.
对两例脂肪母细胞瘤病进行了电子显微镜检查。每例中都存在从成熟脂肪细胞到未分化间充质细胞的一系列脂肪细胞分化。细胞具有各种形状，彼此松散相连，并与含有稀疏胶原和蛋白聚糖颗粒的基质中的小血管松散相连。脂肪细胞和成脂母细胞有一层离散的基膜，但未成熟间充质细胞中不存在，未成熟间充质细胞有突出的中间丝（10纳米）微丝，几乎没有或没有脂滴。两例均无类似棕色脂肪组织或冬眠瘤的病灶（大的多边形细胞彼此紧密相邻并与毛细血管紧密相邻，有密集排列的多形性线粒体和局灶性起伏的质膜内陷）。脂肪母细胞瘤病的超微结构及其在光学显微镜下特征性的松散小叶排列都与人类胎儿的“白色”脂肪组织非常相似。
