Department of Breast Surgery, Nanjing Liuhe District Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu, China.
Department of Pharmacy, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
Chin J Physiol. 2023 Jul-Aug;66(4):257-265. doi: 10.4103/cjop.CJOP-D-22-00117.
Breast cancer (BC) is the most common tumor in women, and its incidence is increasing, ranking first among female malignant tumors. It is urgently needed to find new and reliable biomarkers of BC and to understand the cellular changes that cause metastasis. Stomatin-like protein-2 (SLP-2) is a member of the stomatin protein superfamily. Studies have shown that SLP-2 was highly expressed in some tumors and played an important role in tumor genesis and development. SLP-2 regulated the extracellular signal-regulated kinase (ERK) pathway, and activation of ERK phosphorylated FOXO3a, which was involved in BC progression. However, its possible role in the progression of BC remains unclear. In this study, we found the high expression of SLP-2 in BC tissues and cells. SLP-2 promoted the viability of BC cells. In addition, we found that SLP-2 stimulated the motility of BC cells in vitro. Mechanically, our results revealed that SLP-2 could mediate FOXO3a expression and ERK signaling pathway, thereby contributing to the viability and motility of BC cells. Therefore, SLP-2 has the potential to serve as a promising target for BC treatment.
乳腺癌（BC）是女性最常见的肿瘤，其发病率正在增加，在女性恶性肿瘤中排名第一。迫切需要寻找新的、可靠的 BC 生物标志物，并了解导致转移的细胞变化。Stomatin-like protein-2 (SLP-2) 是 stomatin 蛋白超家族的一员。研究表明，SLP-2 在一些肿瘤中高度表达，在肿瘤发生和发展中发挥重要作用。SLP-2 调节细胞外信号调节激酶（ERK）途径，ERK 的激活使 FOXO3a 磷酸化，这与 BC 的进展有关。然而，其在 BC 进展中的可能作用尚不清楚。在这项研究中，我们发现 SLP-2 在 BC 组织和细胞中高表达。SLP-2 促进了 BC 细胞的活力。此外，我们发现 SLP-2 刺激了 BC 细胞在体外的迁移能力。从机制上讲，我们的结果表明 SLP-2 可以介导 FOXO3a 的表达和 ERK 信号通路，从而促进 BC 细胞的活力和迁移能力。因此，SLP-2 有可能成为 BC 治疗的一个有前途的靶点。
