[Interrelation of the clinical picture of hypothyroidism with the calcium-regulating function of the thyroid in its diffuse enlargement].

Analysis was made of the correlation between the clinical manifestations of hypothyrosis and thyroid calcium-regulating activity. In diffuse enlargement of the thyroid gland the employment of mathematical analysis of hypothyrosis symptoms and thyrotropin-releasing hormone test promoted the early diagnosis of hypothyrosis and helped to reveal its pathogenesis (primary, hypophyseal, hypothalamic). In primary hypothyrosis, when the basal level of thyrotropin and its reaction to TRH was increased, depressed levels of parathormone and thyroxin-binding globulin were observed. A tendency towards elevation in the production of calcitonin was recorded in all mild forms of the disease.