Karetnikov Iu P, Romanova L F, Vasil'eva I V
Probl Endokrinol (Mosk). 1986 Jul-Aug;32(4):14-8.
Analysis was made of the correlation between the clinical manifestations of hypothyrosis and thyroid calcium-regulating activity. In diffuse enlargement of the thyroid gland the employment of mathematical analysis of hypothyrosis symptoms and thyrotropin-releasing hormone test promoted the early diagnosis of hypothyrosis and helped to reveal its pathogenesis (primary, hypophyseal, hypothalamic). In primary hypothyrosis, when the basal level of thyrotropin and its reaction to TRH was increased, depressed levels of parathormone and thyroxin-binding globulin were observed. A tendency towards elevation in the production of calcitonin was recorded in all mild forms of the disease.
对甲状腺功能减退症的临床表现与甲状腺钙调节活性之间的相关性进行了分析。在甲状腺弥漫性肿大时，对甲状腺功能减退症症状进行数学分析并进行促甲状腺激素释放激素试验，有助于甲状腺功能减退症的早期诊断，并有助于揭示其发病机制（原发性、垂体性、下丘脑性）。在原发性甲状腺功能减退症中，当促甲状腺激素的基础水平及其对促甲状腺激素释放激素的反应升高时，观察到甲状旁腺激素和甲状腺素结合球蛋白水平降低。在该病的所有轻度形式中，均记录到降钙素产生有升高的趋势。
