García-Alonso Yesenia, Alonso-Martínez Alicia M, García-Hermoso Antonio, Legarra-Gorgoñon Gaizka, Izquierdo Mikel, Ramírez-Vélez Robinson
Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Spain.
CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain.
Front Pediatr. 2023 Aug 10;11:1168253. doi: 10.3389/fped.2023.1168253. eCollection 2023.
Quantitative diagnostic ultrasound has been proposed as a way to characterize muscle structure, but there is a lack of normative data for children. This study aims to establish age-specific normal ranges for echo-intensity (EI), cross-sectional area (CSA), muscular thickness (MT), and subcutaneous adipose thickness (SAT) values of the rectus femoris muscle in typically developing children. The study recruited 497 children (288 boys and 209 girls) aged 4-10.9 years (mean age 7.39 years), and muscle parameters were measured using 2D B-mode ultrasound. Percentile values and reference curves were calculated using the Lambda, Mu, and Sigma method (LMS). The results showed small variation between measurements for boys compared to girls, with the most significant difference in EI, CSA, and MT values. EI decreased with age, with the most pronounced curve in boys. SAT increased in both sexes, with a slightly higher increase in girls after the age of 9.0 years. This study provides the first age-specific reference norms for the rectus femoris muscle architecture in children, and further research is needed to validate these curves and determine their clinical utility.
定量诊断超声已被提议作为一种表征肌肉结构的方法，但儿童缺乏规范性数据。本研究旨在为发育正常儿童的股直肌回声强度（EI）、横截面积（CSA）、肌肉厚度（MT）和皮下脂肪厚度（SAT）值建立特定年龄的正常范围。该研究招募了497名4至10.9岁（平均年龄7.39岁）的儿童（288名男孩和209名女孩），并使用二维B型超声测量肌肉参数。使用Lambda、Mu和Sigma方法（LMS）计算百分位数和参考曲线。结果显示，与女孩相比，男孩测量值之间的差异较小，EI、CSA和MT值差异最为显著。EI随年龄增长而降低，男孩的曲线最为明显。SAT在两性中均增加，9.0岁后女孩的增加幅度略高。本研究提供了首个儿童股直肌结构的特定年龄参考标准，需要进一步研究以验证这些曲线并确定其临床实用性。
